柔性聚氨泡工人对酸的职业暴露:暴露水平和风险评估
Fatima den Ouden1, Patrick de Kort2, Yu Ait Bamai1,3
1Toxicological Centre, University of Antwerp, Universiteitsplein 1, Wilrijk 2610, Belgium.
Annals of work exposures and health
|January 21, 2026
概括
在欧洲聚氨泡工厂中暴露于Tris () 酸盐 (TCPP) 的工人显示代谢物水平高于一般人群. 然而,风险评估证实,在测量水平上,TCPP暴露没有致癌风险.
科学领域:
- 职业健康 职业健康 职业健康
- 环境化学环境化学
- 毒理学 毒理学 毒理学
背景情况:
- 酸 (TCPP) 是一种用于制造聚氨泡的阻燃剂.
- 该行业的工人面临TCPP的潜在皮肤和吸入暴露.
研究的目的:
- 评估欧洲聚氨泡工人中TCPP暴露水平.
- 使用新确立的衍生无影响水平 (DNEL) 进行风险评估.
主要方法:
- 在使用LC-MS/MS的5家工厂的28名工人中测量了TCPP (BCIPHIPP和BCIPP) 的尿中代谢物.
- 计算了TCPP的估计每日摄入量 (EDI).
- 将EDI与从慢性致癌性研究中得出的DNEL进行比较.
主要成果:
- 在工人的尿液中检测到TCPP代谢物BCIPHIPP和BCIPP.
- 在100%的样本中检测到BCIPHIPP,总体上BCIPP在31% (93%在一个工厂).
- 估计的每日摄入量 (EDI) 显著低于3.0 mg/kg bw/day的确定的DNEL (超过2个数量级).
结论:
- 尽管代谢物水平高于一般人群,但TCPP暴露对受研究的工人没有致癌风险.
- 目前工厂的安全措施被认为足以保护工人免受不良健康影响.
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