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神经功能连接和随着年龄增长的大脑体积损失之间的解离:静止状态磁脑电图的见解
Yuga Takeda1, Jun-Ichi Uemura1, Satsuki Yamauchi2
1Department of Integrative Health Sciences, Faculty of Medicine, Nagoya University, Nagoya, Japan.
大脑体积和神经功能连接 (FC) 随着年龄的增长而下降. 虽然FC变异性也在下降,但一些体积损失的大脑区域显示功能保留,这表明了补偿性适应.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 脑部成像 脑部成像
背景情况:
- 与年龄相关的大脑体积损失是一个已知的现象.
- 神经功能连接 (FC) 随着年龄的增长而发生变化,但其与结构衰退的关系需要进一步研究.
研究的目的:
- 为了检查与年龄相关的大脑体积减少和神经功能连接的改变之间的相关性.
- 为了确定是否具有显著体积损失的特定大脑区域表现出相应的功能连接变化.
主要方法:
- 在75名健康成年人 (20-86岁) 中利用静止状态磁脑电图 (MEG) 和MRI.
- 计算了全脑体积和神经功能连接,使用阿尔法频段的振幅包相关性 (AEC).
- 在66个功能分片中分析了年龄,大脑体积,平均AEC和AEC标准偏差 (SD) 之间的相关性.
主要成果:
- 随着年龄的增长,整个大脑体积显著减少 (r=-0.322,p=0.00480),75岁以上的人明显丧失.
- 平均神经连接率 (AEC) 随着年龄的增长而下降 (r=-0.359,p=0.00153),在年轻人 (<45) 和老年人 (>75) 群体之间显示出显著的差异.
- 随着年龄的增长,AEC的标准偏差也在整个大脑中减少 (r=-0.326,p=0.0043).
- 与其他地区相比,有7个与年龄相关的体积损失显著的地区并不总是显示AEC或其SD发生变化.
结论:
- 大脑体积和神经功能连接都表现出与年龄相关的下降.
- 随着年龄的增长,观察到功能连接的变化减少.
- 局部功能性适应可能会补偿特定大脑区域与年龄相关的结构性衰退.
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