在临床前的肺辐射模型中,质子闪光疗法的局部正常组织节约效应
Sung Eun Lee1, Heesoon Sheen1, Yeeun Kim1
1Department of Radiation Oncology, Samsung Medical Center, Seoul, Republic of Korea.
The British journal of radiology
|January 21, 2026
概括
高剂量的质子FLASH放射治疗通过减轻氧化应激和炎症,显著减少了小鼠的肺部和皮肤损伤. 这项临床前研究支持质子FLASH-RT.
科学领域:
- 辐射瘤学 辐射瘤学
- 临床前研究 临床前研究
- 医学物理 医学物理
背景情况:
- 闪光辐射疗法 (FLASH-RT) 使用超高剂量率 (>40 Gy/s) 进行潜在的正常组织节约.
- 局部胸部FLASH-RT效应,特别是在质子方面,尚不清楚.
- 以前的研究主要集中在全器官辐射上.
研究的目的:
- 评估局部高剂量质子FLASH-RT对肺和皮肤的影响.
- 在临床前模型中,将FLASH-RT (500 Gy/s) 与常规剂量速率 (2 Gy/s) 进行比较.
- 研究正常组织保护的分子机制.
主要方法:
- 一个临床前的小鼠模型接受了60 Gy质子辐射到左肺.
- 辐射以FLASH (500 Gy/s) 或常规 (2 Gy/s) 剂量速率进行.
- 通过组织学,流细胞计和ELISA评估了肺和皮肤反应.
主要成果:
- 与传统RT相比,FLASH-RT显著减少了肺肺炎和纤维化.
- 皮肤毒性,包括表皮厚化和皮肤纤维化,在FLASH-RT.使用时显著降低.
- FLASH-RT降低了氧化应激标志物 (例如8-OHdG),炎症 (例如MPO,IL-6,TNF-α) 和全身炎症指标 (中性粒细胞与淋巴细胞的比率).
结论:
- 在消耗剂量 (>60 Gy) 的质子FLASH-RT提供了针对辐射诱导的肺和皮肤损伤的局部保护.
- FLASH-RT减轻了氧化和炎症反应,阐明了FLASH效应的机制.
- 结果支持高剂量质子FLASH-RT用于胸部应用的潜力,需要进一步进行剂量反应和临床配置研究.
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