机械大动脉置换后出现的出血类型
Ruixin Lu1, Michael Dismorr1,2, Natalie Glaser1,3
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
概括
机械大动脉置换 (AVR) 患者经常经历重大出血事件. 胃肠道和内出血是最常见的并发症,强调了需要改进的预防策略.
科学领域:
- 心脏病学 心脏病学
- 血管外科 血管外科
- 公共卫生 公共卫生
背景情况:
- 机械大动脉提供耐用性,但需要终身抗凝治疗.
- 抗凝治疗增加了出血并发症的风险.
- 机械主动脉置换 (AVR) 后的特定出血模式没有得到很好的描述.
研究的目的:
- 调查机械AVR后主要出血并发症的类型和发生率.
- 在有机动动脉的患者中识别最频繁的出血部位.
主要方法:
- 在瑞典 (1997-2022年) 进行全国性的观察性队列研究.
- 包括所有通过SWEDEHEART注册表识别的接受机械AVR的患者.
- 主要结局:第一个需要住院的重大出血事件,使用瑞典国家患者登记册的国际疾病分类 (ICD) 代码进行识别.
主要成果:
- 13,508名患者接受了机械AVR;15% (2029) 经历了重大出血事件.
- 胃肠道出血 (40%) 和内出血 (24%) 是最常见的并发症.
- 20年后,胃肠道出血的累积发病率为9.0%,内出血为5.3%.
结论:
- 胃肠道和内出血占主导地位,是机械AVR后的出血并发症.
- 血和表也是一种严重的出血问题.
- 需要进一步的研究,以制定降低该患者群体出血风险的策略.
更多相关视频
相关概念视频
01:22Bleeding in Fresh Concrete
548
Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
548
01:16Heart Valves
11.3K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
11.3K
01:30Continuous Renal Replacement Therapy
924
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
924
01:27Mitral Valve Prolapse I: Introduction
416
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
416
03:06Reaction Mechanisms
30.6K
Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
30.6K
01:15Aortic Regurgitation I: Introduction
531
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
531