对创伤性脑损伤的光学连贯性断层扫描视网膜生物标志物:系统性审查和元分析
Abolfazl Hassani1, Lydia Gultom1, Timothy Liang1
1Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
Clinical & experimental optometry
|January 21, 2026
概括
光学连贯断层扫描 (OCT) 在创伤性脑损伤 (TBI) 后显示了各种视网膜变化. 虽然一些研究表明,视网膜神经纤维层在运动员和退伍军人中变薄,但分析发现没有显著的全球效应,这表明需要更多的研究.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 创伤性脑损伤 (TBI) 会导致认知,心理和神经障碍.
- 视网膜是中枢神经系统的延伸,提供了一个非侵入性窗口,用于使用光学连贯断层扫描 (OCT) 评估大脑病理.
研究的目的:
- 系统地审查和对TBI患者的OCT衍生的视网膜变化进行现有研究进行元分析.
- 评估这些视网膜变化的潜力,作为TBI的生物标志物.
主要方法:
- 对五个电子数据库进行了系统搜索,以确定相关研究.
- 包括七项研究,比较TBI患者和对照者之间的OCT参数 (视神经,黄斑和胸腔厚度).
- 进行了随机效应元分析来综合发现,并进行了质量评估.
主要成果:
- 周状视网膜神经纤维层 (RNFL) 厚度的发现是异质的,一些研究表明变薄,特别是在碰撞运动运动员和退伍军人中.
- 一项元分析表明,TBI对RNFL厚度的总体影响很小,不显著 (估计1-1.5μm的稀释).
- 在拳击手中观察到黄斑厚度和质细胞复合体厚度的减少,在TBI患者中减少了亚叶胆道厚度.
结论:
- 来自海外的视网膜生物标志物,特别是RNFL厚度,显示TBI的变化.
- 目前的元分析没有产生显著的总体结果,强调需要进一步进行纵向研究,以确定可靠的OCTTBI生物标志物.
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