萨西图祖马布戈维特康加布利祖马布治疗高级三阴性乳腺癌
Sara M Tolaney1, Evandro de Azambuja2, Kevin Kalinsky3
1Dana-Farber Cancer Institute, Harvard Medical School, Boston.
The New England journal of medicine
|January 21, 2026
概括
沙西图祖马布 (Sacituzumab govitecan) 与潘布罗利祖马布 ( pembrolizumab) 结合,显著改善了晚期三阴性乳腺癌的无进展生存率. 这种组合疗法为PD-L1阳性疾病患者提供了新的选择.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 临床试验 临床试验
背景情况:
- 三阴性乳腺癌 (TNBC) 是一种具有有限治疗选择的侵袭性亚型.
- 对于在晚期,PD-L1阳性,不可切除或转移性TNBC中改善结局的未满足需求存在.
- 编程死亡干1 (PD-L1) 阳性是TNBC治疗选择中的关键生物标志物.
研究的目的:
- 为了评估sacituzumabgovitecan加pembrolizumab的疗效和安全性,与化疗加pembrolizumab相比.
- 确定这种组合对以前未经治疗的高级TNBC无进展生存 (PFS) 的影响.
- 评估二次终点,包括总生存率,客观反应率,反应持续时间和安全性.
主要方法:
- 第三阶段,开放标签,国际随机试验.
- 1:1随机分配到萨基图祖马布 (govitecan + pembrolizumab) 或化疗 + pembrolizumab.
- 主要终点:通过盲目独立的中央审查进行PFS;次要终点:OS,ORR,DOR,安全.
主要成果:
- 萨西图祖马布 (govitecan + pembrolizumab) 显示PFS中位数显著长 (11.2个月) 与化疗 + pembrolizumab (7.8个月) 相比.
- 客观应答率为sacituzumab govitecan + pembrolizumab的60%,而化疗 + pembrolizumab的53%.
- 3级以上的不良事件相似 (71%vs70%),但由于AEs的治疗中止在sacituzumab govitecan (12%vs31%) 较低.
结论:
- 在第一线高级TNBC中,sacituzumab govitecan加上 pembrolizumab与化疗加上 pembrolizumab相比,显示出优越的PFS.
- 这种组合代表了PD-L1阳性高级三阴性乳腺癌患者的显著进展.
- 这项研究由吉利德科学公司资助,注册号为ASCENT-04/KEYNOTE-D19 (NCT05382286).
相关概念视频
Scalar and Vector Triple Products
4.4K
Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.4K
Negative Regulator Molecules
38.3K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.3K
Positive, Negative, and Zero Work
22.0K
Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.0K
Extraction: Advanced Methods
1.1K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K
Negative and Cognitive Symptoms of Schizophrenia
499
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
499
Overview of Advanced Functional Groups
29.3K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.3K


