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在现实世界中检测了偏磁边缘病变及其与多发性硬化症疾病负担的关联
Olavi Misin1, Anni Piispanen2, Markus Matilainen1
1Turku PET Centre, Turku University Hospital, University of Turku, and Åbo Akademi University, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland; Clinical Neurosciences, University of Turku, Turku, Finland; InFLAMES Research Flagship, University of Turku, Turku, Finland.
偏磁边缘病变 (PRLs) 表明多发性硬化症 (MS) 中正在进行的炎症. 这项研究发现,PRL的存在和数量与增加的MS严重程度,残疾和大脑体积损失有关.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 偏磁边缘病变 (PRL) 是多发性硬化症 (MS) 的新兴MRI生物标志物.
- PRLs反映了MS大脑中的活跃,燃烧着的炎症,其特点是含铁的巨细胞和微质细胞.
- 检测PRL可以作为MS中正在进行的炎症过程的代理.
研究的目的:
- 在常规临床环境中识别偏磁边缘病变 (PRLs).
- 在MS患者中调查PRL负担与临床/准临床参数之间的关联.
- 评估PRL识别用于监测MS进展的可行性.
主要方法:
- 从206名多发性硬化症患者的3T脑部MRI扫描的回顾性审查 (2021年9月至2023年12月).
- 在敏感度加权成像 (SWI) 过相位图像上视觉识别PRL.
- 脑体积数据的自动定量和临床变量的手动图表审查.
主要成果:
- 34%的患者至少有一次PRL (PRL1+组).
- PRL数量与扩展残疾状况量表 (EDSS),多发性硬化症严重性评分 (MSSS) 和T2损伤体积正相关.
- 与没有PRL的患者相比,患有PRL的患者表现出明显较小的thalamic体积.
结论:
- 现实世界的数据证实PRL与更严重的MS有关.
- 使用标准SWI过相位图像进行PRL识别是一种可行的临床工具.
- PRLs可以作为一个有价值的成像参数来评估MS中与进展相关的病理.
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