饮食中的乌罗素a通过Nrf2信号通路激活改善了老的肝脏抗氧化功能和产卵性能
Liuting Wu1, Yibiao Zhang1, Leilei Peng1
1State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, PR China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, PR China.
Poultry science
|January 21, 2026
概括
食乌罗立A (UA) 补充剂通过增强抗氧化能力和免疫功能来改善产母母的表现. 200 mg/kg UA的最佳剂量激活了Nrf2通路,促进了健康和卵子的产生.
科学领域:
- 动物科学动物科学
- 营养生物化学 营养生物化学
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 由于肝氧化应激,老龄化产母的生产率下降,免疫应激增加.
- 乌罗立A (UA) 是一种天然代谢物,在哺乳动物中激活了Nrf2抗氧化途径,但其对产母的影响尚不清楚.
研究的目的:
- 调查饮食UA对产卵母健康和产量的剂量反应影响.
- 阐明UA在母激活Nrf2通路中的作用.
主要方法:
- 五十只45周大的产卵母被食了6周的0,50,200,400或800毫克/公斤UA的饮食.
- 评估生产性能,器官指数,血清/肝脏脂质概况,抗氧化剂状况,免疫标志物,肝脏组织学和Nrf2通路表达.
- 利用体外初级肝细胞模型来证实UA的直接作用.
主要成果:
- 200 mg/kg UA显著改善了产卵率,蛋重量和料与蛋的比例,同时降低了血清胆固醇和甘油三.
- 这一剂量还增强了抗氧化能力 (TAC,SOD,GSH-Px),增加了免疫球蛋白 (IgY,IgA) 和降低了脂质过氧化 (MDA).
- UA上调肝脏Nrf2通路mRNA和蛋白质表达,效果在体外得到证实.
结论:
- 食UA补充剂,特别是200mg/kg,可以提高母的晚期产卵性能.
- 通过Nrf2通路激活,UA可以改善抗氧化能力,脂质代谢和免疫功能.
- UA显示出作为天然料添加剂的潜力,可以维持蛋生产的峰值.
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