洛伦兹场对伤口愈合的影响的研究:理论,计算和实验分析分析
Aliye Gürcan1, Merve Açıkgöz1, Rabia Tutuk1
1Biomedical Engineeering, Inonu Universitesi, Inonu Universitesi Muhendislik Fakultesi F Blok, Biyomedikal Muhendisligi Bolumu, Battalgazi, Malatya, 44000, TURKEY.
Physics in medicine and biology
|January 21, 2026
概括
这项研究提出了一种新的非侵入性方法,用于使用超声波和磁场组合生成洛伦茨场的伤口愈合. 这种方法可以安全有效地加速伤口关闭,优于控制和单一模式治疗.
科学领域:
- 生物医学工程 生物医学工程
- 医学物理 医学物理
背景情况:
- 非侵入性治疗方式对于加速伤口愈合至关重要.
- 目前的方法可能缺乏局部刺激或需要直接接触.
- 洛伦兹场为非侵入性组织刺激提供了一个潜在的机制.
研究的目的:
- 引入和评估一种新的非侵入性伤口愈合方法,利用在静态磁场下超声传感器产生的洛伦兹场.
- 从理论上建模并从数值上模拟该技术的可行性和有效性.
- 为了在动物模型中比较超声波-磁场联合疗法的疗效与个体疗法和对照组的疗效.
主要方法:
- 对于洛伦茨场生成的治理方程的理论导出.
- 数字模拟包括伤口几何,皮肤层和传感器配置 (单元和线性相位阵列).
- 分析不同激发模式下的压力和电流密度分布 (探头,光束转向,聚焦).
- 进行14天的动物实验,以评估伤口关闭率.
主要成果:
- 模拟证明了可行性,计算了在安全范围内的电流密度和压力.
- 单元探头: ~4.51 μA/cm2 电流密度,0.17 MPa 压力.
- 线性阶段阵列 (LPA) 束方向:均分布,±0.118-0.203 MPa压力,±2.33-2.69 μA/cm2电流密度.
- LPA聚焦:峰值压力为0.285 MPa,峰值电流密度为6.72 μA/cm2.
- 动物研究表明,洛伦茨场组的伤口关闭速度最快.
结论:
- 结合超声波和磁场的方法有效地产生局部的洛伦兹场,用于非侵入性伤口刺激.
- 这种方法证明了一种有前途且安全的替代方法,可以加速伤口愈合.
- 该技术提供局部刺激,而不需要直接接触电极.
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