在老年人中,基于动态图的身体活动和认知衰老的访问到访问变化之间的并发关联
Ranjani P Shankar1, Rowan Saloner1, Coty Chen1
1Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Neurobiology of aging
|January 21, 2026
概括
增加每天步骤与更好的执行功能和老年人较少的抑郁症状有关. 这突显了体力活动 (PA) 如何随着时间的推移影响认知衰老和心理健康.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 身体活动 (PA) 在降低痴呆风险方面发挥着重要作用.
- 客观地测量PA与大脑和认知衰老相关的纵向研究很少,这限制了对大脑行为关联的暂时性理解.
研究的目的:
- 调查客观测量的身体活动 (每日步数) 和认知功能 (记忆,执行功能),大脑结构 (海马体积,白质超强度) 和老年人抑郁症状的变化之间的纵向关系.
主要方法:
- 107名老年人每年接受神经心理测试和脑磁共振成像.
- 用30天的Fitbit监测在多次研究访问中测量了目标PA.
- 线性混合效应模型分析了随着时间的推移,步数变化与大脑/认知结果之间的关联.
主要成果:
- 在人体内,每日步数的增加与执行功能的改善有显著的关联 (Std. β = 0.128,p ≤ 0.001) 和抑郁症状的减少 (Std. β = -0.201,p ≤ 0.001) 的情况.
- 在身体活动变化与记忆,海马体积或白质超强度之间没有发现统计学上显著的纵向关联.
结论:
- 身体活动的变化可能会影响老年人实时认知能力下降的风险.
- 基于动态图的运动监测显示了与衰老相关的早期神经行为变化检测的潜力.
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