环境长期暴露于空气污染和表观遗传衰老时钟:系统性审查和元分析
Charalampia Ioannou1, Tim S Nawrot2, Dries S Martens1
1Centre for Environmental Sciences, Hasselt University, Diepenbeek 3590, Belgium.
Ecotoxicology and environmental safety
|January 21, 2026
概括
环境空气污染可能对生物衰老的影响很小,但目前的证据缺乏统计学意义. 这次审查发现PM2.5等污染物与使用Horvath时钟的表观遗传年龄加速之间没有显著的联系.
科学领域:
- 环境健康 环境健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 环境空气污染是一个全球性的健康问题.
- 生物衰老可以使用表观遗传钟来评估.
- 空气污染对表观遗传衰老的影响需要进一步研究.
研究的目的:
- 系统地审查和元分析长期暴露于环境空气污染物和表观遗传衰老加速 (EAA) 之间的关联.
- 评估特定的污染物,包括颗粒物 (PM2.5,PM10),二氧化 (NO2) 和黑碳 (BC).
主要方法:
- 在PubMed,Scopus和谷歌学者数据库中进行系统搜索.
- 使用随机效应模型估计关联的元分析.
- 包括18项研究,共363,381名参与者.
主要成果:
- 在PM2.5,PM10,NO2或BC和Horvath EAA.之间没有发现统计学意义上的关联.
- 对成年人的敏感性分析显示,对PM2.5.5的影响更为明显,尽管在统计学上并不显著.
- 时代和灰时代EAA显示不一致或没有与空气污染物暴露的关联.
结论:
- 这一元分析表明,在成年人中,粒子空气污染和Horvath EAA之间存在潜在的弱,但不具有统计学意义的联系.
- 其他表观遗传时钟没有显示一致的关联.
- 需要进一步进行高质量的纵向研究,以阐明空气污染与表观遗传衰老之间的关系.
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