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暴露组和人类口腔微生物组通过一个健康镜头
Luis Limo1, Justin Donovan2, Stephanie Frisbee2
1Dentistry, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, Ontario N6A 3K7, Canada; Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, Ontario N6A 3K7, Canada.
Archives of oral biology
|January 21, 2026
概括
终身暴露 (暴露组) 影响口腔微生物群,影响口腔疾病. 在了解非细菌群落和对口腔健康的长期影响方面存在研究差距.
科学领域:
- 口腔微生物组研究
- 暴露体科学 暴露体科学
- 一个健康计划的倡议.
背景情况:
- 人口微生物组受到生物,环境和社会因素的复杂相互作用的影响,这些因素被统称为exposome.
- 了解这些相互作用对于在"一个健康"框架内解决口腔疾病的发展和进展至关重要.
研究的目的:
- 绘制和综合当前证据,揭露对人类口腔微生物群的影响.
- 探索暴露和口腔疾病的发展和进展之间的关系.
主要方法:
- 根据Arksey和O'Malley框架进行了全面的范围审查.
- 在多个数据库 (MEDLINE,Embase,PsycInfo,Scopus,Web of Science,CINAHL) 中进行了搜索.
- 通过Joanna Briggs Institute (JBI) 工具评估研究质量,并根据PRISMA-ScR指南进行报告.
主要成果:
- 29项研究表明,健康状况,疾病,药物和心理社会因素影响口腔微生物群的生物多样性,丰富性和功能.
- 动物相互作用,物理和化学暴露可以改变宿主微生物群相互作用和口腔微生物群体动态.
- 研究虽然在方法上是健全的,但由于样本规模小和对混因素的控制有限,研究质量中等.
结论:
- 人口微生物组与暴露组的相互作用是复杂的,影响疾病和健康行为.
- 关于非细菌群落,相互作用机制和对抗生素疾病的长期影响的研究仍然存在差距.
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