聚乙烯微塑料的表面电荷依赖性卵巢毒性:对积累,线粒体损伤和巨细胞两极分化的洞察
Ke Xu1, Wanting Du1, Yuchen Hou1
1Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei 430079, China.
Journal of hazardous materials
|January 21, 2026
概括
微塑料表面功能群显著影响卵巢积累和毒性. 功能化微塑料 (MP) 破坏激素平衡,增加氧化应激,促进铁,突出显示生殖健康风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 环境老化改变了微塑料 (MP) 的功能组,可能影响它们的生物影响.
- 功能化MPs对卵巢功能和毒性的特定影响尚不清楚.
研究的目的:
- 调查口服暴露后大鼠卵巢中具有不同表面功能组 (PS-NH2,PS,PS-COOH) 的聚乙烯MPs的积累和毒性.
- 阐明表面功能化和充电在MP引起的卵巢损伤和生殖健康风险中的作用.
主要方法:
- 通过口服给大鼠使用不同的功能化PS-MPs.
- 在卵巢组织中分析MP积累.
- 评估卵巢功能,包括性激素水平,氧化应激标志物和线粒体损伤.
- 评估巨细胞透,铁积累和铁.
- 研究巨细胞两极分化 (M1/M2表型).
主要成果:
- 卵巢中MP的积累按照以下顺序进行:PS-NH2 > PS > PS-COOH.
- 暴露于MPs,特别是PS-NH2,破坏了性激素平衡,增加了氧化应激,并导致线粒体损伤.
- 所有测试的MP都增加了巨细胞的透和铁的积累,诱导卵巢细胞中的铁亡.
- 负电荷的PS-COOHMP促进了M1巨细胞的两极分化,加剧了氧化应激和卵巢损伤.
结论:
- 表面功能和电荷是MP卵巢毒性的关键决定因素.
- 国会议员通过涉及激素干扰,氧化应激,线粒体功能障碍和铁亡的机制诱导卵巢损伤.
- 调查结果提供了与MP相关的生殖健康风险的见解,并为减轻暴露危害的策略提供了信息.
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