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走向更安全的深溶性溶剂:从不同制备方法下对毒性进行体内研究的见解
Yua Kang1, Seong Min Lee1, Seulgi Kang1
1School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea.
Journal of hazardous materials
|January 21, 2026
概括
制备方法显著影响深层欧特溶剂 (DES) 的安全性. 加热DES产生的有毒副产品,如氨,造成伤害,而冷干燥避免这些问题,使DES更安全的应用.
科学领域:
- 绿色化学是一种绿色化学.
- 毒理学 毒理学 毒理学
- 材料科学是一种材料科学.
背景情况:
- 深度环氧溶剂 (DES) 正在成为传统挥发性有机溶剂的环保替代品.
- 对于DES制备方法的毒理影响,特别是加热,尚不清楚.
- 了解制剂依赖性毒性对于安全的DES应用至关重要.
研究的目的:
- 为了区分DES制备方法引起的体内毒性与内在溶剂效应.
- 为了研究使用reline (胆化物:尿素) 作为模型的毒性机制基础.
- 为了比较传统加热 (reline_H) 与冷干燥 (reline_FD) 线的安全性.
主要方法:
- 通过加热 (reline_H) 和冷干燥 (reline_FD) 制备reline.
- 在ICR小鼠中进行体内毒性评估,剂量为1.8g/kg.
- 机理学研究包括氧化还原平衡,代谢负担和氨清除分析.
主要成果:
- 在小鼠中,reline_H诱导了腐蚀性症状和胃损伤,而reline_FD则耐受良好.
- 冷干燥 (reline_FD) 由固有的成分造成了可控的代谢负担.
- 加热 (reline_H) 导致由于氨副产品的性损伤,导致氧化还原失衡和线粒体损伤.
结论:
- 雷林的毒性主要是由于热生成的副产品 (如氨) 的性压力.
- 冷干燥是一种更安全的制备方法,可以避免有毒副产品的形成.
- DES的安全性严重依赖于其制备史,而不仅仅是其成分,需要对生物应用进行仔细考虑.
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