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前脑小脑的特征与儿童发病的系统性红斑狼的认知功能障碍有关
Hanne Van der Heijden1, Gabrielle Alonzi2, Amanda Cao1
1Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA USA.
Seminars in arthritis and rheumatism
|January 21, 2026
概括
儿童开始的系统性红斑狼 (cSLE) 患者表现出与前脑小脑异常相关的认知功能受损. 这项研究强调了cSLE中的大脑差异,影响了认知灵活性和工作记忆.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 认知功能障碍 (CD) 在儿童开始的全身性红斑狼 (cSLE) 中很常见.
- 了解cSLE中CD的神经行为基础对于有效管理至关重要.
研究的目的:
- 研究患有系统性红斑狼的儿科患者认知功能障碍的神经行为基础.
- 在cSLE中识别认知缺陷的神经成像相关物.
主要方法:
- 20名cSLE患者和20名健康对照 (HCs) 接受了神经认知测试,问卷和神经成像 (fNIRS,fMRI,结构性MRI).
- 临床状态使用系统性狼红斑血病活动指数2000和实验室标记物进行监测.
- 基于神经成像资料,K-means集群被用来识别cSLE队列中的子组.
主要成果:
- 与HC相比,cSLE患者表现出更差的认知功能,更高的情绪困扰和更多的身体症状.
- 神经成像显示在认知任务期间前额皮层和前额皮层/小脑活动发生变化,以及前额-小脑连接受损.
- 在cSLE患者中观察到前额和小脑区域灰质的减少和白质连接的改变.
结论:
- 前脑小脑异常与儿童发作的系统性红斑狼的认知功能障碍有关.
- 这些发现强调了需要进行多学科研究,以了解cSLE中CD的神经生物学.
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