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Updated: Jan 23, 2026

Isolation and Purification of Murine Cardiac Pericytes
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向瘤关联细胞中的TCF21-TCF3异构体,通过恢复细胞守门员功能来减轻血液转移

Wenqian Yin1, Haiqin Yao2, Xiaobo Li1

  • 1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, China; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, Guangdong, China.

Cell reports. Medicine
|January 21, 2026
PubMed
概括

研究人员在瘤周细胞中发现了一种TCF21-TCF3转录因子,该因子驱动癌症转移. 一种针对这种相互作用的新可以通过恢复细胞周围细胞功能,在临床前模型中显著抑制转移.

关键词:
在TCF21-TCF3异构聚合物中.这是一种抑制剂.周围细胞 (pericytes) 是一个细胞.瘤转移的发生.

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