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纵向体重指数是基于暴露的值,用于预防2型糖尿病患者的死亡率
Tingting Hu1, Renzhi Cai2, Yiting Xu1
1Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
Cell reports. Medicine
|January 21, 2026
概括
对于患有2型糖尿病的老年人来说,保持体重指数 (BMI) 在27kg/m2以下与更好的生存率有关. 持续高的BMI会增加死亡风险.
科学领域:
- 老年学是指老年学的学科.
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生 公共卫生
背景情况:
- 对于预防2型糖尿病 (T2DM) 的老年人死亡的最佳长期体重指数 (BMI) 值还没有得到很好的定义.
- 了解BMI的长期影响对于管理T2DM并发症和改善老年人寿命至关重要.
研究的目的:
- 确定40岁及以上的T2DM成年人与死亡风险相关的长期BMI值.
- 量化BMI暴露指标 (时间超过/在目标范围内) 与全因,心血管和癌症死亡率之间的关系.
主要方法:
- 利用了3,708名患有T2DM的成年人 (≥40岁) 的队列,并在4年内至少进行5次BMI测量.
- 评估BMI暴露使用目标范围以上时间的百分比 (TAR) 和目标范围内的时间的百分比 (TTR).
- 随访参与者平均5年,记录了1020例死亡;这些发现在中国健康与退休纵向研究队列中得到了验证.
主要成果:
- 持续的BMI≥27 kg/m2 (TAR) 显示与死亡风险增加有积极的关联.
- 体重指数在18.5-26.9公斤/平方米 (TTR) 范围内持续时间较长,证明了剂量反应生存益处.
- 这些好处扩展到所有原因,心血管和癌症死亡率 (所有p <0.05).
结论:
- 中年和老年2型糖尿病患者死亡风险升高的关键值是持续暴露于27kg/m2或更高的BMI.
- 保持BMI在特定的目标范围内提供了显著的,剂量依赖的生存优势.
- 这些发现为T2DM患者的体重管理策略提供了基于证据的指导,以改善长期结果.
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