在患有多囊性卵巢综合征的女性中,下丘脑-垂体-上腺轴活动和月经不规则之间的关系
Ali Zeynettin1, Orhan Balikci1, İsmail Demir2
1Department of Internal Medicine, İzmir City Hospital, İzmir, Türkiye.
Clinical and experimental reproductive medicine
|January 21, 2026
概括
在患有多囊性卵巢综合征 (PCOS) 的女性中,月经不规律与代谢和炎症标志物有关,而不是直接与感知压力有关. 在这项研究中,压力评分并不能独立预测不规则的月经.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 代谢综合征是代谢综合征的一种.
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病,影响生殖和代谢健康.
- 月经不规律是PCOS的标志性症状,影响生育能力和生活质量.
- 在PCOS中,压力,下丘脑-垂体-上腺 (HPA) 轴和代谢功能障碍之间的相互作用需要进一步阐明.
研究的目的:
- 调查HPA轴活动,感知压力和PCOS妇女的代谢标记之间的关系.
- 确定感知到的压力是否是PCOS中月经不规则的独立预测因素.
- 通过代谢和炎症因素探索潜在的间接途径,通过代谢和炎症因素将压力和月经功能障碍联系起来.
主要方法:
- 对296名患有PCOS的女性进行了回顾性横截面研究,按月经状况分类 (常规,寡妇,无月经).
- 评估荷尔蒙,代谢和生化参数,以及使用感知压力量表 (PSS-10) 感知压力量表的感知压力.
- 统计分析包括相关性,多变量后勤回归和接收器操作特征 (ROC) 分析.
主要成果:
- 感知压力量表 (PSS) 的得分与胰岛素抵抗 (HOMA-IR),皮质醇,上腺皮质激素 (ACTH) 和高灵敏性C反应蛋白 (hs-CRP) 有正相关.
- 恶化的月经不规则与增加的HOMA-IR,hs-CRP和PSS得分有关.
- 虽然HOMA-IR独立预测了 amenorrhea,但PSS得分在调整混因素后并不是月经不规则的独立预测因素.
结论:
- 在PCOS中,月经不规律与代谢和炎症标志物相比,与感知到的压力本身更为密切相关.
- 通过PSS-10测量的感知压力不是PCOS妇女月经不规则的独立预测因素.
- 观察到的压力和月经不规则之间的关联可能由代谢和炎症途径介导.
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