使用普罗波的静脉全麻醉有效地为Cynomolgus雄性子 (Macaca fascicularis) 提供轻度麻醉平面,这些子接受了无感热刺激
Mingyun Zhang1, Kenzie Schwartz1, Michael Klukinov2
11Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California.
概括
在重复的热刺激试验中,普罗波连续速率输液 (CRI) 有效地在Cynomolgus子中提供轻度麻醉. 生理学参数保持稳定,表明该物种可靠的麻醉方案.
科学领域:
- 兽医麻醉学 兽医麻醉学
- 灵长类动物研究研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 关于在Cynomolgus子中用于全静脉麻醉时使用Propofol的数据有限.
- 对于涉及这些非人类灵长类动物的临床前研究来说,研究普罗波对轻度麻醉的疗效至关重要.
研究的目的:
- 评估普罗波连续速率输液 (CRI) 在Cynomolgus中维持轻度麻醉的有效性.
- 评估生理参数的稳定性,在重复的可感受性测试中进行可感受性测试.
主要方法:
- 四只雄性Cynomolgus子接受了胺/德克斯梅德托米丁,与阿提帕梅佐尔逆转,其次是普罗波福尔CRI (8-16 mg/kg/h).
- 物理参数 (血压,心率,呼吸率,SpO2,温度) 持续监测.
- 使用阿贡激光热刺激进行的可感受性测试每周进行一次,持续六周,根据需要调整醇剂量.
主要成果:
- 轻度麻醉所需的普罗波福尔剂量在整个六周的研究期间保持一致.
- 在重复麻醉和测试期间,在生理参数中没有观察到统计学上显著的变化.
- 普罗波CRI有效地维持了轻度麻醉,没有对生命体征产生不良影响.
结论:
- 8-16毫克/公斤/小时的普罗波CRI是实现Cynomolgus的轻度麻醉的可靠方法.
- 这种麻醉方案支持在Cynomolgus子中进行重复的感知测试,这对于临床前研究至关重要.
- 稳定的生理学参数表明,用于扩展研究应用,propofol CRI在这种物种中耐受性良好.
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