通过磁场调节骨重塑:一种针对糖尿病骨质疏松症代谢失调的方法

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...

A moving charge or a current creates a magnetic field in the surrounding space, in addition to its electric field. The magnetic field exerts a force on any other moving charge or current that is present in the field. Like an electric field, the magnetic field is also a vector field. At any position, the direction of the magnetic field is defined as the direction in which the north pole of a compass needle points.
A magnetic field is defined by the force that a charged particle experiences...

A solenoid is a conducting wire coated with an insulating material, wound tightly in the form of a helical coil. The magnetic field due to a solenoid is the vector sum of the magnetic fields due to its individual turns. Therefore, for an ideal solenoid, the magnetic field within the solenoid is directly proportional to the number of turns per unit length and the current. Conversely, the magnetic field outside the solenoid is zero.
Consider a solenoid with 100 turns wrapped around a cylinder of...

The representation of magnetic fields by magnetic field lines is very useful in visualizing the strength and direction of the magnetic field. Each of the magnetic field lines forms a closed loop. The field lines emerge from the north pole (N), loop around to the south pole (S), and continue through the bar magnet back to the north pole.
Magnetic field lines follow several hard-and-fast rules:

If a magnetic field is sustained, there must be a current in a closed circuit or loop, implying some energy has been spent in creating the field. If this energy is not dissipated via the circuit's resistance, it is stored in the field.
Take an ideal inductor with zero resistance. Although it's practically impossible, assume that the coil's resistance is so small that it is practically negligible. The loss of the field's energy to dissipate thermal energy (or heat) is thus...