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Updated: Jan 23, 2026

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免疫检查点抑制剂相关心肌炎的趋势:十年的见解
Milagros Pereyra Pietri1, Juan M Farina1, Isabel G Scalia1
1Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ, USA.
International journal of cardiology
|January 21, 2026
概括
免疫检查点抑制剂 (ICI) 相关心肌炎 (ICIrM) 诊断正在增加,这可能是由于更好的认识和诊断方法. 这一趋势凸显了随着ICI使用的增长,需要改进监测和早期检测策略.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
- 免疫检查点抑制剂相关心肌炎 (ICIrM) 是一种罕见但严重的不良事件.
- 最近ICIrM发病率和诊断的趋势尚不清楚.
研究的目的:
- 分析ICI使用和ICIrM诊断的时间趋势.
- 调查ICIrM的诊断流行率的变化.
- 评估诊断标准对ICIrM认可的影响.
主要方法:
- 对11602名接受ICI治疗的患者 (2011-2024) 的回顾性审查.
- 手动查看图表,以确定ICIrM病例.
- 描述性分析ICI治疗使用和ICIrM发生率随着时间的推移.
主要成果:
- 在1.1%的患者 (n=127) 中发生了ICIrM.
- 在2023-2024年观察到ICIrM诊断的显著增加 (47.2%的病例).
- 诊断患病率从2020年之前的0.5%上升到2020年后的1.3%,与指导方针实施相吻合.
结论:
- 越来越多的ICIrM发病率很可能是由提高临床意识和诊断实践驱动的.
- 改善监测和早期检测对于管理ICIrM至关重要.
- 随着ICI治疗的使用在全球范围内扩大,需要采取积极的战略.
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