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胎儿生长限制对心血管结构和功能的长期影响:对生长不一致的同卵双胞胎进行的一组研究

Jip A Spekman¹, Sophie G Groene¹, Monique C Haak²

¹Division of Neonatology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.

The Journal of pediatrics

|January 21, 2026

概括

胎儿生长限制 (FGR) 与儿童心脏功能的持久变化有关,即使在同卵双胞胎中也是如此. 这表明增长受限制的个体的长期心血管疾病风险增加.

科学领域:

心血管生理学心血管生理学
儿童心脏病学儿童心脏病学
围产儿医学围产儿医学

背景情况:

胎儿生长限制 (FGR) 是影响长期健康的一个重大问题.
同卵双胞胎研究提供了一个独特的模型来控制遗传和环境因素.
了解FGR后的儿童心血管适应对于预测未来疾病风险至关重要.

研究的目的:

评估FGR对儿童心血管结构和功能的影响.
使用一种生长不一致的同卵双胞胎模型来隔离FGR效应.
研究在子宫内暴露于FGR的个体中持续的心血管重塑.

主要方法:

在42个生长失调的同卵双胞胎组 (5-17岁) 中进行前性心声扫描.
由≥20%的出生体重差异定义的生长不一致.
较小 (FGR) 和较大的共同双胞胎之间的结构 (LV维度,cIMT) 和功能 (LV菌株,扩张功能,aPWV) 参数的比较.

主要成果:

更小的双胞胎表现出明显减少的LV全球纵向菌株.
在较小的双胞胎中观察到更高的中峰E和A速度和E/e'比率.
在同胞双胞胎之间,在结构性心血管参数 (LV尺寸,cIMT,aPWV) 中没有发现显著差异.

结论:

在儿童时期,FGR与心肌功能的亚临床变化 (心缩和心缩) 有关.
这些发现表明,在FGR之后,持续的不良心血管改造.
在FGR后的儿童心血管变化可能表明心血管疾病的长期风险增加.

关键词:

双胞胎是单胆子双胞胎.大动脉脉冲波速度的速度.頸動脈內膜介質厚度頸動脈內膜介質厚度超声心电图 (Echocardiography) 是一种心声回声仪.选择性的胎儿生长限制.

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