决策树算法与哈里斯-博伊德标准相结合的优点和应用,用于构建妊娠期间凝血指标的动态参考间隔
Xiaosong Lin1, Zhi Lin2, Liangjie Xu3
1Clinical Laboratory Department, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, Fujian Province, China.
Clinical biochemistry
|January 21, 2026
概括
怀孕凝血指标的动态参考间隔 (RIs),使用与哈里斯-博伊德标准 (DTAHBC) 的决策树算法,比传统方法更好地反映高凝血状态的变化. 这种方法可以提高怀孕期间评估凝血功能的准确性.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 临床化学 临床化学
背景情况:
- 怀孕凝血指标的传统参考间隔 (RIs) 可能无法捕捉动态的高凝血状态变化.
- 基于妊娠年龄的固定RI可能会导致怀孕期间的评估不准确.
研究的目的:
- 评估将决策树算法 (DTA) 与哈里斯-博伊德标准 (DTAHBC) 集成的有效性,以建立动态RI.
- 开发更准确的凝血指标RI,反映怀孕期间动态变化的凝血指标.
主要方法:
- 追溯分析了来自4,698名健康孕妇的凝血数据 (PT,INR,APTT,TT,Fib,D-d,FDP).
- 利用DTA来识别凝血指标中的动态拐点,通过哈里斯-博伊德标准验证.
- 使用第2.5个百分点和第97.5个百分点计算了新的RI,并将其与传统的基于季度的RI进行了比较.
主要成果:
- PT,INR,APTT和TT保持稳定,而Fib,D-d和FDP在怀孕期间显著增加.
- DTA识别了与传统的三个月划分不一致的拐点,检测出高凝血的早期和晚期.
- 新的基于DTAHBC的RI显示了90%以上的合规性,超过了未能对TT和D-d进行验证的传统RI.
结论:
- 基于DTAHBC的RI提供了更准确的怀孕期间动态凝血变化的反映,偏离了传统的三个月划分.
- 这种新的方法为评估孕妇的凝血功能提供了改进的解决方案.
- 动态RI对于精确监测怀孕期间的高凝血能力至关重要.
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