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基于素-蜘蛛丝-石墨烯量子点的pH响应洋结构的水凝珠,用于控制药物输送
G A Nethumini Kaushalya Gunawardhana1, Yern Chee Ching2, Hemanth Noothalapati3
1Department of Polymer Science, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, 10250, Sri Lanka; Centre for Nanocomposite Research, Faculty of Applied Science, University of Sri Jayewardenepura, Gangodawila, 10250, Nugegoda, Sri Lanka.
International journal of biological macromolecules
|January 21, 2026
概括
由奇托桑和蜘蛛丝制成的pH响应的水凝珠提供受控的多克索鲁比辛输送. 这些珠子,结合石墨烯量子点,显示增强的抗菌性质和向瘤微环境,克服癌症治疗的挑战.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 癌症治疗面临着诸如药物向不良和突发释放等挑战.
- 素 (Cs) 和蜘蛛丝 (SS) 是具有药物输送潜力的生物相容聚合物.
- 石墨烯量子点 (GQD) 为跟踪提供独特的光特性.
研究的目的:
- 开发适应pH的多层水凝珠,用于可控的多克索鲁比 (DOX) 输送.
- 将GQD纳入光追踪和评估抗菌性质.
- 通过向药物释放来克服传统癌症治疗的局限性.
主要方法:
- 使用奇托和蜘蛛丝制造的水凝珠,与酸交叉连接.
- 提取蜘蛛丝,保留β-sheet结构;通过热解合成的GQDs.
- 在不同pH值 (4和7) 的体外药物释放研究.
- 用于结构特征的SEM分析;进行了抗菌试验.
主要成果:
- 单层珠子表现出pH值依赖的胀,在酸性条件下 (550%) 与基性条件下 (90-110%) 的胀更高.
- 在实验室中,DOX释放在pH 4 (84%) 与pH 7 (21%) 相比显示出显著的释放,表明瘤向.
- 多层珠子在5小时内显著减少了爆裂释放 (40%),与单层珠子 (80%) 相比.
- 蜘蛛丝增强增强机械强度;珠子显示抗菌活性.
结论:
- 开发了pH响应的多层水凝珠,使用奇托,蜘蛛丝和GQDs进行受控的DOX输送.
- 水凝系统通过在瘤微环境中释放药物来证明有针对性癌症治疗的潜力.
- 材料的组合提供了增强的机械性能,光和抗菌活性.
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