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早期阶段试验的疗效和安全效应估计在第三阶段试验中进行测试时会回归

Angela Nelson1, Hannah Moyer1, Karine Vigneault1

  • 1Department of Equity, Ethics and Policy, McGill University, Montreal, Quebec, Canada.

Journal of clinical epidemiology
|January 21, 2026
PubMed
概括

对于固体瘤的早期药物试验往往高估了疗效. 第三阶段试验显示回归到平均值,这意味着结果往往不如最初的Ib/II阶段发现.

关键词:
临床试验中的临床试验.药物开发 药物开发伦理学 伦理学 伦理学超级研究 (Meta-Research) 是一种研究方法.在瘤学瘤学.第二阶段第二阶段监管部门的批准风险 风险 风险 风险 风险

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