轻度急性缺血性中风后使用阿司匹林-提卡格勒:从获得指导方针-中风注册表的发现
Ava L Liberman1, Cenai Zhang1, Sara K Rostanski2
1Clinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine.
概括
尽管有指导方针,阿司匹林-蒂卡格勒勒很少用于预防轻度缺血性中风. 随着时间的推移,阿司匹林-蒂卡格雷勒和阿司匹林-克洛皮多格雷尔的使用在这个患者群体中增加了.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 临床药房 临床药房
背景情况:
- 目前的指导方针建议在轻度急性缺血性中风中使用阿司匹林-蒂卡格雷勒来预防中风.
- 这种双重抗血小板治疗 (DAPT) 方案在现实世界中的利用仍然不清楚.
研究的目的:
- 为了确定在轻度急性缺血性中风患者中使用阿司匹林-蒂卡格勒的频率.
- 分析DAPT处方的趋势和与阿司匹林-蒂卡格勒勒使用相关的因素.
主要方法:
- 对"了解指导方针" - 脑卒中注册表 (2017-2023) 的横截面分析.
- 包括轻度缺血性中风 (NIHSS <6) 没有DAPT禁忌的患者.
- 使用后勤回归来识别与阿司匹林-蒂卡格雷勒处方相关的因素.
主要成果:
- 在超过100万名患者中,只有1.3%的患者在出院时接受了阿司匹林-蒂卡格勒.
- 亚司匹林-克洛皮多格瑞尔被处方给了44.0%的患者.
- 在研究期间,两种DAPT疗法的使用量都增加了.
- 与阿司匹林-蒂卡格勒勒相关的因素包括冠状动脉疾病和亚洲种族;农村环境和初级中风中心相反地相关.
结论:
- 阿司匹林-蒂卡格勒勒很少用于轻度急性缺血性中风,与指南形成鲜明对比.
- 随着时间的推移,阿司匹林-蒂卡格雷勒和阿司匹林-克洛皮多格雷尔的处方量都增加了.
- 可能需要进一步的研究来了解阿司匹林-蒂卡格勒或采用障碍.
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