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Updated: Jan 23, 2026

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在LIN28A-依赖的基因组和蛋白质组重编程促进伊马替尼布耐药性

Owen F J Hovey1, Mallory I Frederick1, Quan M Quach1

  • 1Department of Biochemistry and, Western University, London, ON, N6A 5C1, Canada.

Molecular & cellular proteomics : MCP
|January 21, 2026
PubMed
概括

林28A是一种过度表达在耐伊马替尼布慢性髓性白血病 (CML) 中的蛋白质,通过协调酶网络来驱动耐药性. 针对LIN28A或其下游激酶,如PKC,可以克服对BCR-ABL氨酸激酶抑制剂 (TKI) 的耐药性.

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