相关实验视频
Updated: Jan 23, 2026

05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
2.2K
多基因分析显示,在侵袭性甲状腺癌亚型中,有明显的免疫抑制和代谢失调
Shanying Gui1, Kate Huang2, Jianling Qiang3
1School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Molecular & cellular proteomics : MCP
|January 21, 2026
概括
侵袭性甲状腺癌 (无塑性和差异化) 具有共同的分子特征,与乳腺状甲状腺癌不同. 像FCGR2A这样的生物标志物可能有助于诊断侵袭性甲状腺癌和开发向治疗.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺癌是一种异质性疾病,临床结果各不相同.
- 侵袭性亚型,形甲状腺癌 (ATC) 和差分甲状腺癌 (PDTC),需要进一步的分子和免疫特征.
研究的目的:
- 为了划分甲状腺癌亚型的分子和免疫景观.
- 为了确定潜在的甲状腺癌 (ATC和PDTC) 的生物标志物.
主要方法:
- 在120个甲状腺瘤样本中的甲状腺瘤样本 (FFPE) 上进行多组组特征分析 (4D-DIA蛋白质组和总RNA-seq).
- 分析包括35个ATC,18个PDTC,37个乳头甲状腺癌 (PTC) 和30个相邻的正常组织 (N).
主要成果:
- ATC和PDTC显示出显著的分子相似性,与PTC和正常组织不同.
- 侵略性亚型表现出丰富的免疫相关和代谢途径,表明明显的免疫抑制.
- 中性细胞细胞外陷 (NET) 形成和M0巨细胞积累被确定为ATC和PDTC中的关键免疫抑制机制.
- 对IgG受体IIa (FCGR2A) 的Fc片段作为ATC的潜在生物标志物出现.
结论:
- 甲状腺癌亚型的综合分子和免疫学表征提供了对ATC和PDTC病原性的洞察.
- 研究结果表明,对于侵袭性甲状腺癌的潜在诊断和治疗点,包括精密治疗的FCGR2A.
相关概念视频
Aggression
30.1K
Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
30.1K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K
What is Metabolism?
131.3K
Overview
131.3K
The Thyroid Gland
6.8K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.8K
Adrenergic Receptors: ɑ Subtype
2.8K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
2.8K
Adrenergic Receptors: β Subtype
3.7K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
3.7K

