综合评估动脉硬和右心房功能在2型糖尿病与心血管自主神经病变的2型糖尿病
Tsuyoshi Tabata1, Kazuhiro Shimizu2, Toshio Kinoshita1,2
1Department of Clinical Functional Physiology, Toho University Sakura Medical Center.
概括
2型糖尿病中的心血管自主神经病 (CAN) 与动脉硬和右心房功能受损有关. 早期检测可能包括评估动脉硬性和右心房张力.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 心血管自主神经病变 (CAN) 是2型糖尿病 (T2DM) 的重要并发症.
- 动脉硬和右心房 (RA) 功能对CAN发展的具体贡献尚不清楚.
研究的目的:
- 研究T2DM患者的动脉硬,右心房 (RA) 功能和心血管自主神经病变 (CAN) 之间的关联.
- 澄清动脉硬和RA功能在CAN病理生理学中的作用.
主要方法:
- 在120名T2DM患者中评估了短期心率变化 (CVR-R) 来定义CAN (CVR-R <2%).
- 测量了动脉硬度的心血管指数 (CAVI),并使用二维斑点跟踪心声学 (2DSTE) 进行RA功能评估.
- 采用多变量分析来确定CAN的独立预测因素.
主要成果:
- 较高的CAVI (动脉硬) 独立地与CAN相关.
- 较低的RA功能复合分数也与CAN独立相关.
- 这些发现强调了动脉硬,RA功能和T2DM中的CAN之间的重要联系.
结论:
- 动脉硬度增加和RA功能受损是T2DM中CAN的特征特征.
- 这些因素表明,在CAN中,心血管系统的相互作用至关重要.
- 对CAVI和RA菌株的联合评估可能有助于更好地早期检测Can.
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