在基于挤出的生物打印中,可 perfusable 芯片的模型设计和路径优化:将水凝病变与结构特征联系起来
Jiahao Wu1,2, Zhitong Li2, Weilin Meng1,2
1State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang 150080, China.
ACS biomaterials science & engineering
|January 21, 2026
概括
这项研究通过将水凝特性与结构设计和路径规划联系起来,优化了基于挤出的生物打印. 这使得复杂的,可 perfusable 3D 细胞培养系统的创建具有改进的制造能力.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 基于挤出的生物打印提供了精确的控制,成本效益和多功能性.
- 有限的研究存在于材料特性,结构设计和生物打印过程优化之间的相互作用.
研究的目的:
- 调查水凝类风湿学,模型结构特征和路径规划策略之间的关系.
- 优化生物打印工艺,制造复杂的3D结构,包括不支持的悬架和可 perfusable 芯片.
主要方法:
- 使用图案数组和3D网格构造,评估了低粘度和高粘度水凝的打印能力.
- 设计并打印了一个具有各种特征 (平面,支,墙壁,悬架) 的透气芯片.
- 基于水凝的风学特性优化打印路径,以克服制造无支悬架的局限性.
主要成果:
- 低粘度的水凝适用于频繁挤出变化的图案;高粘度的水凝更适合支架.
- 成功制造了一个10 × 10mm2的悬浮结构和可 perfusable 水凝芯片.
- 制造的芯片显示出可靠的流量性能和密封能力,最大破裂压力为1.2kPa.
结论:
- 开发了一个设计框架,整合了材料特性,结构特征和路径规划.
- 该框架优化了基于挤出的生物打印工艺,用于先进的3D细胞培养系统.
- 这项研究为构建复杂的生物打印架构提供了宝贵的见解.
相关概念视频
Mean free path and Mean free time
5.0K
Consider the gas molecules in a cylinder. They move in a random motion as they collide with each other and change speed and direction. The average of all the path lengths between collisions is known as the "mean free path."
5.0K
Path Between Thermodynamics States
3.9K
Consider the two thermodynamic processes involving an ideal gas that are represented by paths AC and ABC in Figure 1:
3.9K
Structure-Activity Relationships and Drug Design
1.7K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.7K
Covalently Linked Protein Regulators
8.8K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
8.8K
Interference: Path Lengths
1.9K
Consider two sources of sound, that may or may not be in phase, emitting waves at a single frequency, and consider the frequencies to be the same.
Two special sources may be considered when they are in phase. This can be easily achieved by feeding the two sources from the same source. An example would be synchronizing the two speakers by feeding them with the same source, such as the sound waves produced by a tuning fork. This setup ensures that the two sources have the same frequency and are...
Two special sources may be considered when they are in phase. This can be easily achieved by feeding the two sources from the same source. An example would be synchronizing the two speakers by feeding them with the same source, such as the sound waves produced by a tuning fork. This setup ensures that the two sources have the same frequency and are...
1.9K
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion
31.2K
Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
31.2K


