皮诺雷西诺二甲化物减轻后肢卸载诱导的小鼠骨损失
Ying-Ying Xuan1, Liang Li1, Yi Wu1
1Fundamental Medical Science Research laboratories, People's Liberation Army Joint Logistic Support Force 940th Hospital, Lanzhou 730050, PR China.
Life sciences in space research
|January 21, 2026
概括
皮诺雷西诺二甲化物 (PDG) 有效地防止了由模拟微重力和后肢卸载引起的骨损失. 这种天然化合物保护骨细胞,减少氧化应激,并保持骨密度和强度.
科学领域:
- 太空医学 太空医学
- 骨生物学 骨生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 微重力引起的骨损失是宇航员面临的主要挑战.
- 现有的对策不足以防止与太空飞行相关的骨密度减少.
- 来自Eucommia ulmoidis Oliv的pinoresinol diglucoside (PDG) 在骨健康方面显示出潜力.
研究的目的:
- 调查PDG在预防微重力诱导的骨损失方面的有效性.
- 为了评估PDG在模拟微重力 (SMG) 下对骨质母细胞的影响.
- 评估PDG对后肢不负荷的小鼠骨健康的影响.
主要方法:
- 培养的老鼠骨质细胞暴露于SMG.
- 没有后肢的小鼠被口服PDG治疗了21天.
- 分析骨矿物质密度,微观结构,强度,细胞亡,氧化应激和炎症标志物.
主要成果:
- PDG预防了SMG诱导的骨质母细胞功能障碍,细胞亡和细胞循环停止.
- 在没有负荷的小鼠中,PDG逆转了骨损失,改善了骨的微观结构和强度.
- PDG抑制了骨细胞亡,氧化应激,炎症和骨再吸收.
结论:
- PDG有效地抵消与微重力和不使用相关的骨损失.
- PDG通过抑制亡,氧化应激和炎症来保护骨.
- PDG是预防太空飞行引起的骨损失和骨质疏松症的有希望的候选人.
相关概念视频
Line Loss
517
The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
517
Reducing Line Loss
370
In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
370
Major Losses in Pipes
1.9K
When a fluid flows through a pipe, it experiences energy losses due to frictional resistance along the pipe walls, known as major losses. These energy losses result in a pressure drop, which varies based on the flow conditions — whether laminar or turbulent — and the specific physical properties of the fluid and pipe.
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
1.9K
Minor Losses in Pipes
1.9K
In pipe systems, minor losses refer to energy losses arising from components such as valves, bends, fittings, expansions, and other features that disrupt the steady flow of fluid. These disturbances cause energy dissipation through turbulence and resistance, which engineers quantify to manage system efficiency effectively.
Valves play a significant role in generating minor losses by obstructing or redirecting the fluid flow. When a valve is closed or partially closed, it restricts the flow...
Valves play a significant role in generating minor losses by obstructing or redirecting the fluid flow. When a valve is closed or partially closed, it restricts the flow...
1.9K
Energy Losses in Transformers
1.3K
In an ideal transformer, it is assumed that there are no energy losses, and, hence, all the power at the primary winding is transferred to the secondary winding. However, in reality, the transformers always have some energy losses, and, hence, the output power obtained at the secondary winding is less than the input power at the primary winding due to energy losses.
There are four main reasons for energy losses in transformers.
The first cause can be the high resistance of the...
There are four main reasons for energy losses in transformers.
The first cause can be the high resistance of the...
1.3K
Three-Phase Short Circuit—Unloaded Synchronous Machine
679
Conducting a three-phase short circuit test on an unloaded synchronous machine helps understand its impact on the system. The AC fault current's oscillogram, with the DC offset removed, reveals that the waveform amplitude decreases from an initially high value to a steady-state level for one phase of the machine.
This behavior occurs due to the magnetic flux produced by the short-circuit armature currents. Initially, these currents follow high-reluctance paths but eventually shift to...
This behavior occurs due to the magnetic flux produced by the short-circuit armature currents. Initially, these currents follow high-reluctance paths but eventually shift to...
679


