对于PitNETs的内透镜内透膜外科手术 (EETS):十年来在一个机构的结果
Jamie Rosen1,2,3, Zenab Sher2, Pratibha Natesh4,5
1Warwick Medical School, University of Warwick, Medical School Building, Coventry CV4, United Kingdom.
Neuro endocrinology letters
|January 21, 2026
概括
内透镜内透膜外科手术 (EETS) 有效治疗垂体神经内分泌瘤,改善视野. 复发预测因素需要进一步调查,而不仅仅是Ki-67指数.
科学领域:
- 神经外科 神经外科
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 下垂体神经内分泌瘤 (PitNETs) 是复杂的瘤,需要有效的外科治疗.
- 内镜内透膜外科手术 (EETS) 已成为切除这些瘤的主要方法.
- 评估长期结果,组织病理学和复发模式对于优化患者护理至关重要.
研究的目的:
- 评估十多年来用EETS治疗的PitNET的结果,病原体和复发率.
- 分析手术并发症和EETS在改善患者症状,如视野缺陷等方面的有效性.
- 确定手术干预后瘤复发的潜在预测因素.
主要方法:
- 在2013年至2024年期间接受EETS的152名患者进行了回顾性,横截面研究.
- 分析患者的人口统计,瘤组织病理学和手术并发症.
- 评估结果,包括瘤复发和视野缺陷的改善.
主要成果:
- 宏腺瘤 (87.5%) 是主要的瘤类型,其中淋巴细胞瘤是最常见的亚型 (47.4%).
- 复发发生在19.1%的患者中,其中11.8%需要重新手术;33.6%经历并发症,包括CSF泄漏 (9.9%).
- 在术后观察到视野显著改善,复发瘤显示基-67指数低 (0-3%).
结论:
- 对于PitNETs来说,EETS是一种安全有效的外科手术方式,产生与现有文献相一致的结果.
- 手术导致视野缺陷的显著改善.
- 单独Ki-67指数不足以预测复发;需要考虑放射学,生物化学和其他组织病理学标记的多式方法.
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