全球皮质薄化预测在多发性硬化症中前后步行速度较慢
A S Monaghan1, P G Monaghan2, T N Takla3
1School of Psychology, Queen's University Belfast, UK.
The European journal of neuroscience
|January 21, 2026
概括
扩散性皮质稀疏与多发性硬化症 (MS) 中的慢步速度有关. 这种大脑变化会影响向前和向后行走,影响移动性.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 在多发性硬化症 (MS) 中,走路障碍和跌倒是普遍存在的,这显著影响了患者的流动性和生活质量.
- 在MS中移动性下降的潜在神经机制,特别是关于分散的皮质变化和复杂的步行任务,如倒行,需要进一步阐明.
研究的目的:
- 研究MS患者的扩散性皮质稀疏和步行速度 (前进和后退) 之间的关联.
- 为了确定这种关联是否在跌倒的人和不跌倒的人之间有所不同.
主要方法:
- 43名多发性硬化症患者接受了高分辨率的结构性MRI,以评估皮质厚度和灰质体积.
- 前进和后退定时25英尺步行测试用于测量步行速度.
- 用错误发现率 (FDR) 校正的回归分析来检查神经成像测量和步行速度之间的关系.
主要成果:
- 全球皮质稀薄成分与MS患者的前后步行速度减慢有显著的相关性.
- 皮层厚度和灰质体积变化都不能以特定区域的方式预测步行速度.
- 虽然落者和非落者在步行速度或皮质稀薄方面没有区别,但探索性分析表明,在落者中皮质稀薄和步行之间存在潜在的更强的关联,尽管在FDR校正后,这种关联在统计学上并不显著.
结论:
- 扩散皮质稀薄是多发性硬化症中步伐减慢的一致的神经相关物.
- 这些发现强调了广泛的皮质完整性对于维持MS的步行功能的重要性.
- 初步证据表明,皮质稀薄和步态之间的关系可能在最近经历过跌倒的个体中更加明显.
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