能量电荷的时空调节决定了T细胞的功能
Aleksandra S Chikina1, Béatrice Corre1, Fabrice Lemaître1
1Institut Pasteur, Université de Paris Cité, INSERM U1223, Paris, France.
Nature communications
|January 21, 2026
概括
免疫细胞能量水平因位置和时间而异,影响T细胞功能. 了解这些能量差异是调节免疫反应的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞的新陈代谢
- 系统生物学 系统生物学
背景情况:
- 免疫细胞功能与分化,转录和表观遗传调节有关.
- 细胞代谢对于免疫细胞的能量产生至关重要,但能量充电动态仍然不清楚.
研究的目的:
- 为了研究免疫细胞能量充电在不同解剖位置和时间的变化.
- 为了确定免疫细胞的能量负荷是否影响细胞功能.
主要方法:
- 使用SPICE-Met分析ATP:ADP比率,细胞能量指标,在复杂的细胞群体中 in vivo.
- 血液中的T细胞与淋巴结的能量充电比较,并在一天中的不同时间进行比较.
主要成果:
- 具有高糖解能力的免疫细胞 (效应T细胞,NK细胞) 显示出最高的ATP:ADP比率.
- 效应T细胞在血液中表现出比淋巴结更高的能量电荷,这与葡萄糖的可用性有关.
- 昼夜节律影响了能量充电,在早期的休息阶段达到峰值.
- 能量电荷的变化直接影响T细胞功能,特别是IFN-γ的产生.
结论:
- 免疫细胞的能量资源和功能在各个解剖部位和昼夜时间之间有所不同.
- 营养物质的可用性和能量负荷是免疫细胞 in vivo 功能的关键调节者.
- 调节能量负荷和营养的可用性提供了一个潜在的策略来控制免疫反应.
相关概念视频
Atomic Radii and Effective Nuclear Charge
61.7K
The elements in groups of the periodic table exhibit similar chemical behavior. This similarity occurs because the members of a group have the same number and distribution of electrons in their valence shells.
61.7K
Testosterone: Functions and Regulation
2.1K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.1K
Formal Charges
40.1K
In some cases, there are seemingly more than one valid Lewis structures for molecules and polyatomic ions. The concept of formal charges can be used to help predict the most appropriate Lewis structure when more than one reasonable structure exists.
40.1K
Ions and Ionic Charges
78.7K
In ordinary chemical reactions, the nucleus — which contains the protons and neutrons of each atom and thus identifies the element — remains unchanged. Electrons, however, can be added to atoms by transfer from other atoms, lost by transfer to other atoms, or shared with other atoms. The transfer and sharing of electrons among atoms govern the chemistry of the elements. During the formation of some compounds, atoms gain or lose electrons to form electrically charged particles called...
78.7K
Energetics of Solution Formation
7.4K
The formation of a solution is an example of a spontaneous process, which is a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Formation of the solution requires the solute–solute and solvent–solvent...
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Formation of the solution requires the solute–solute and solvent–solvent...
7.4K
pH Regulation in Cells
7.6K
pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
7.6K


