Multiomics对中国儿童的饮食时间模式和心血管风险的洞察力
Qin Liu1, Jingyu Chen1, Xizhou An1
1Department of Epidemiology and Biostatistics, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China.
Nature communications
|January 21, 2026
概括
在儿童中建立一个早餐窗口与更好的心血管健康有关. 这种饮食模式,晚上8点之前吃完饭,显著降低了高血压的风险.
科学领域:
- 儿科心血管健康 儿童心血管健康
- 营养科学 营养科学
- 代谢学 代谢学 代谢学
背景情况:
- 全球儿童心血管风险因素的增加需要早期预防策略.
- 可修改的生活方式因素,包括饮食时间,对于儿科健康至关重要.
- 了解饮食模式对儿童心血管参数的影响至关重要.
研究的目的:
- 研究中国儿童的饮食时间模式与心血管参数之间的关联.
- 确定潜在的代谢媒介,将饮食模式与心血管健康联系起来.
- 为儿童心血管疾病预防提供早期生活方式干预的证据.
主要方法:
- 大规模的队列研究 (n=7459) 分析饮食模式 (延长,晚,早吃窗口).
- 嵌套病例控制研究 (n=51) 用脂质和蛋白质组分析.
- 统计分析包括赔率比率,置信区间,p值和调解分析.
主要成果:
- 较早的进食窗口 (最后一顿饭≤20:00) 与延长的进食窗口相比,与血压升高的风险降低26%有关.
- 蛋白质组分析揭示了83种不同表达的蛋白质,涉及心肌收缩和脂质代谢.
- 鉴定出三糖醇是饮食模式对血压影响的显著媒介 (64.8%).
结论:
- 儿童的早餐时间与保护性心血管参数有关.
- 脂质代谢途径,特别是三糖醇,在调解这些影响方面发挥着关键作用.
- 研究结果支持促进儿童心血管健康的早期饮食模式.
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