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Updated: Jan 23, 2026

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face
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Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face

Published on: January 7, 2019

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结核素皮肤测试的演变揭示了可概括的Mtb反应性T细胞元克隆

Carolin T Turner1, Andreas Tiffeau-Mayer1,2, Joshua Rosenheim1,3

  • 1Division of Infection and Immunity, University College London, London, UK.

Nature communications
|January 21, 2026
PubMed
概括

这项研究表明,特定的T细胞受体 (TCR) 相互作用主导着人类的Mycobacterium结核病 (Mtb) 反应性T细胞反应. 识别这些公共T细胞克隆可以改善结核病患者分层和疫苗开发.

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相关概念视频

The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Convergent Evolution01:54

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Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
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The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
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John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
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Enols are a class of compounds where a hydroxyl group is attached to a carbon–carbon double bond, which implies that it is a vinyl alcohol. A carbonyl compound with an α hydrogen undergoes keto–enol tautomerism and remains in equilibrium with its tautomer, the enol form. Usually, the keto tautomer is present in a higher concentration than the enol tautomer due to the higher bond energy of C=O compared to C=C. Moreover, the direction of the keto–enol equilibrium is...
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