饮食模式和特异性不育男性的精子DNA碎片化:一个病例对照研究
Mahdieh Ganji1, Ghazaleh Eslamian2, Naser Amirjannati3
1Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences, No 7, Hafezi St., Farahzadi Blvd, P.O.Box: 19395-4741, Tehran, 1981619573, Iran.
Scientific reports
|January 21, 2026
概括
饮食模式会影响异常不孕症男性的精子DNA完整性. 植物-鱼类饮食与较低的精子DNA碎片化有关,而半西方和超加工饮食增加碎片化风险.
科学领域:
- 生殖医学 生殖医学
- 营养科学 营养科学
- 遗传学 遗传学 是一个
背景情况:
- 精子DNA碎片化指数 (DFI) 是男性不孕症的关键指标,通常与氧化压力有关.
- 有限的研究存在于整体饮食模式对精子DNA完整性的影响,特别是在男性具有特异性不孕不育.
研究的目的:
- 为了研究经验上获得的饮食模式和被诊断患有异常不孕症的男性的精子DNA碎片化之间的关联.
- 为了确定特定的饮食模式,可能会影响精子DNA完整性在这个人群中.
主要方法:
- 一项涉及300名男性 (150名高DFI,150名低DFI) 的病例控制研究,年龄为18-50岁,患有异常不孕症.
- 饮食摄入量通过168项半定量食物频率调查问卷进行评估.
- 主要组件分析确定了饮食模式;后勤回归分析了高DFI的关联,并调整了混因素.
主要成果:
- 三种饮食模式出现了:植物-鱼类,半西方和超加工.
- 较高的植物-鱼类模式的坚持与较低的高精子DNA碎片化的几率显著相关 (OR=0.39,P趋势<0.001).
- 相反,半西方 (OR=3.06,P-trend=0.008) 和超加工 (OR=3.77,P-trend<0.001) 模式与剂量依赖的方式增加高DFI的几率有关.
结论:
- 坚持植物-鱼类饮食可能有助于防止异常不孕症男性的高精子DNA碎片化.
- 增加半西方和超加工饮食的消费与精子DNA碎片化的风险更高有关.
- 综合的饮食评估对于男性不孕症的管理很重要,尽管观察数据排除了因果推断.
关键词:
案例控制研究研究.伊朗 伊朗 伊朗 伊朗营养 营养 营养 营养 营养氧化应激是一种氧化应激.植物 - 鱼类的饮食.加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品加工食品生殖健康 生殖健康精子DNA碎片化的情况相关概念视频
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