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结直肠癌幸存者的内在大脑活动和认知衰退的改变空间模式
Brian Ellis1, John Quan Nguyen2, Ian Ray3
1Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL, USA. briane3@illinois.edu.
Journal of cancer survivorship : research and practice
|January 21, 2026
概括
结肠直肠癌幸存者表现出认知能力下降和大脑活动的改变,包括时间过度活跃和破坏默认模式网络连接. 这些神经变化表明对癌症的不适应反应,可能会影响认知功能.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 与癌症相关的认知障碍 (CRCI) 是影响结肠直肠癌 (CRC) 幸存者的普遍问题,即使是那些没有接受化疗治疗的人.
- 了解CRCI的潜在神经机制对于开发有效干预措施至关重要.
研究的目的:
- 调查化学疗法以前的CRC幸存者的自发大脑活动和认知功能.
- 用静止状态功能磁共振成像 (rsfMRI) 和认知评估来识别与癌症有关的神经变化.
主要方法:
- 十九名早期,化学疗法以前的CRC幸存者和18名健康对照人接受了认知测试和rsfMRI.
- 用低频波动 (fALFF) 和功能连接 (FC) 的分数振幅分析了rsfMRI数据.
- 统计分析对年龄,性别,教育,抑郁和焦虑等共变量进行了控制,并对多次比较进行了校正.
主要成果:
- 与对照组相比,CRC幸存者在口头记忆 (HVLT-R RDI) 和心理运动速度 (TMT-A) 的表现较差.
- 在部区域 (海马体,准海马体,状回旋) 观察到增加的fALFF,并在前部区域减少fALFF.
- 在幸存者中发现默认模式网络 (DMN) 中功能连接性降低,时间fALFF与口头记忆缺陷负相关.
结论:
- 从未接受过化疗的CRC幸存者在脑区域表现出过度活跃,并破坏了DMN连接,与认知障碍相关.
- 这些发现表明一种不适应的神经反应有助于CRCI在CRC幸存者的CRCI.
- 确定的神经变化可能成为未来干预的潜在目标,例如神经调节,以减轻CRCI.
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