相关实验视频
Updated: Jan 23, 2026
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
16.5K
潜在的增强局部药物输送使用葡萄衍生纳米颗粒修改使用TAT
Risa Kanai1, Tomohiro Seki1, Tomona Yukimura1
1Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-0295, Japan.
Pharmaceutical research
|January 21, 2026
概括
葡萄衍生纳米颗粒 (GNP) 的表面修饰,用化Tat- (STR-Tat) 增强皮肤透. 这种方法可以通过植物衍生纳米颗粒 (PdNP) 改善核酸的传递,而不会对细胞产生显著的毒性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 皮肤药物输送 皮肤药物输送
背景情况:
- 植物衍生纳米粒子 (PdNPs) 显示出核酸输送的前景,特别是在通过皮肤的应用中.
- 提高PdNP的皮肤透率对于有效的通过皮肤递送至关重要.
- 细胞透 (CPP),如Tat-,可以促进细胞吸收和皮肤透.
研究的目的:
- 评估使用化Tat- (STR-Tat) 的表面修饰来增强葡萄衍生纳米颗粒 (GNP) 透皮肤的可行性.
- 评估STR-Tat修饰对GNP特性,细胞吸收和皮肤透的影响.
- 确定STR-Tat修饰的GNP在通过皮肤输送核酸方面的潜力.
主要方法:
- 通过简单的混合,用合成的STR-Tat进行GNP表面修饰.
- 测量修改GNP (STR-Tat-GNP) 的粒子大小和泽塔潜力.
- 在小鼠模型上进行的体内皮肤透研究,以及体内细胞吸收和毒性测试.
主要成果:
- STR-Tat-GNPs表现出正的泽塔潜力,与未经修改的GNP的负泽塔潜力形成鲜明对比.
- 观察到STR-Tat-GNPs的细胞吸收增强,细胞毒性最小.
- 在体内研究表明,DI标记的STR-Tat-GNP显著透到毛囊和较深的皮肤层.
结论:
- 简单的STR-Tat表面修改有效地提高了GNP的皮肤透率.
- 这种方法可以通过GNP改善脂性物质的传递,而不会引起显著的细胞毒性.
- STR-Tat修饰的GNP代表了开发具有高皮肤透能力的植物衍生纳米颗粒的有希望的战略,用于输送核酸.
相关概念视频
01:16Bioavailability Enhancement: Drug Solubility Enhancement
229
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
229
01:27Bioavailability Enhancement: Drug Permeability Enhancement
194
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
194
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
203
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
203
01:16Drug Delivery: Overview
753
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
753
01:19Antiasthma Drugs: Leukotriene Modifiers
1.8K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
1.8K
01:18Drug Delivery: Enteral Route
1.6K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.6K