在慢性可变应激条件下,尼古丁胺二烯酸对SIRT1/PPARγ通路和紧结蛋白进行调节
Abdullah Celik1, Nurhan Sahin1, Cemal Orhan1
1Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, 23119, Türkiye.
Journal of physiology and biochemistry
|January 21, 2026
概括
尼古丁胺 рибоoside (NR) 补充剂有效地抵消了老鼠的慢性压力影响,改善了肝脏健康,肠道屏障功能和葡萄糖代谢. NR为管理与压力相关的代谢障碍提供了一个有希望的替代方案.
科学领域:
- 代谢健康 代谢健康
- 压力生理学 压力生理学
- 营养生物化学 营养生物化学
背景情况:
- 慢性压力会破坏平衡,导致肝损伤,肠道功能障碍和代谢问题.
- 目前的治疗方法有不良影响,需要更安全的替代方案.
- 尼古丁胺基核糖胺 (NR) 是NAD+的前体,与降低慢性疾病风险有关,但其在压力反应中的作用尚不清楚.
研究的目的:
- 研究NR补充剂对暴露于慢性变量压力 (CVS) 的老鼠的影响.
- 评估NR对肝脏新陈代谢,肠道屏障完整性以及压力下相关蛋白质通路的影响.
主要方法:
- 56只雄性Sprague Dawley大鼠接受了CVS,并接受了不同剂量的NR (0-600 mg/kg) 治疗.
- 分析了生物化学标记物 (葡萄糖,皮质,NAD+),肝脏标记物 (PPARγ,SIRT1) 和肠道蛋白质 (紧密/粘合结).
主要成果:
- CVS增加了葡萄糖,皮质和ACTH,同时降低了NAD+和相关代谢物.
- 补充NR使这些不平衡正常化,并提高肝脏标志物的调节.
- NR增强了肠道运输蛋白和紧/粘合结蛋白,改善了屏障功能.
- 高剂量的NR缓解了肝纤维化和改善了葡萄糖代谢.
结论:
- 补充NR有效地减轻慢性压力引起的肝脏,肠道和葡萄糖失调.
- 在压力下,NR改善了关键的代谢和肠道健康生物标志物.
- 作为与压力相关的代谢障碍的安全替代品,NR显示了治疗潜力.
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