在左上边缘环上进行的正极跨直流刺激对疼痛认知同情感的神经效应
Yumiko Ikeda1, Hidenori Suzuki2, Ryosuke Arakawa2
1Department of Pharmacology, Graduate School of Medicine, Nippon Medical School, 1-25-16, Nezu, Bunkyo-ku, Tokyo, 113-0031, Japan. y-ikeda@nms.ac.jp.
Cognitive, affective & behavioral neuroscience
|January 21, 2026
概括
在左上边缘回形上进行的阴道横直流刺激 (tDCS) 减少了与认知疼痛同理性相关的脑活性. 这种调制可能为治疗慢性疼痛的干预提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 疼痛研究 疼痛研究
背景情况:
- 疼痛同理心,分享和理解他人的痛苦的能力,至关重要,但在神经学上理解得很差.
- 疼痛同理心的障碍与心理健康障碍和慢性疼痛疾病有关.
- 支疼痛同理心的神经机制需要进一步研究.
研究的目的:
- 使用功能磁共振成像 (fMRI) 调查疼痛同理心的神经基质.
- 为了检查在疼痛同理心任务中对左上边缘环 (SMG) 进行的正极跨直流刺激 (tDCS) 对大脑激活的影响.
- 评估tDCS对同情度量和身体疼痛感知的影响.
主要方法:
- 26名健康成年人在左侧SMG上接受了阴极或假的tDCS.
- 基于任务的fMRI被用来测量在对疼痛的认知和情感同理心期间的大脑激活.
- 自我报告的同理心和疼痛评估是在tDCS前后进行的.
主要成果:
- 在对疼痛的认知同理会过程中,阴极tDCS降低了左SMG和右中间额头 (MedFG) 的大脑激活.
- 减少的MedFG激活与认知同情心得分的降低正相关.
- 在具有低特征认知同情的人群中,tDCS诱导的激活减少与身体疼痛止痛有关.
结论:
- 左SMG激活在对疼痛的认知同情中起着重要作用,特别是在具有较低基线特征认知同情的人群中.
- 这些发现突出了疼痛同理心及其调节的神经基础.
- 结果可能有助于开发用于中枢神经系统疼痛条件的新型治疗干预措施.
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