可注射的富血小板纤维素 (i-PRF) 与富血小板纤维素 (PRF) 相比,两者与β-三酸混合,用于使用山羊的甲手臂骨缺陷进行骨再生:微型CT比较研究
Mohammed Assiri1, Hesham Almoallim2, Maryam Alhindi2
1Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Najran University, Najran, Kingdom of Saudi Arabia.
与单独的PRF或β-TCP相比,与β-TCP结合的i-PRF在山羊甲手缺陷中显著增强了骨再生. 这种组合促进了更快,更好的骨愈合,微型CT分析证实了这一点.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 整形外科手术 整形外科手术
背景情况:
- 关键大小的骨缺陷在实现自发再生方面带来了重大临床挑战.
- 富含血小板纤维素 (PRF) 和其先进形式,可注射的PRF (i-PRF),由于其生长因子含量,被用于骨再生.
- β-三酸 (β-TCP) 是一种常用的骨移植材料,为骨形成提供支架.
研究的目的:
- 为了比较i-PRF与β-TCP相结合的疗效,与PRF与β-TCP相结合的疗效,在一只山羊模型中,在关键大小的甲手腕缺陷中促进骨再生.
- 通过微计算机断层扫描 (micro-CT) 分析来评估骨再生率和质量.
主要方法:
- 18只山羊接受了手术创建四个关键大小的缺陷的甲手腕骨.
- 缺陷的治疗方法是:自发愈合 (对照),单独使用β-TCP,β-TCP + PRF或β-TCP + i-PRF.
- 在2,5和8周进行了微CT分析,以评估新的骨形成 (BV-NFB),骨矿物质密度 (BMD-NFB) 和支架退化 (TCPV,TCPMD).
主要成果:
- 与其他组相比,β-TCP + i-PRF组在所有时间点都显示出明显更高的新骨体积 (BV-NFB) 和骨矿物质密度 (BMD-NFB).
- 到第8周,β-TCP + i-PRF组显示出最高的BV-NFB (80.083毫米3) 和BMD-NFB (0.822g/mm3).
- β-TCP + i-PRF 组也表现出轨道膜参数 (厚度,分离,数量) 的有利变化和更快的β-TCP再吸收.
结论:
- 与单独的β-TCP或与PRF结合的β-TCP相比,i-PRF和β-TCP的组合显著提高了临界大小缺陷的再生性骨愈合.
- 微型CT分析证实,通过β-TCP+i-PRF混合物,骨的数量和质量都得到了优异的再生.
- 在指导骨再生程序中,i-PRF显示为增强β-TCP的生物活性成分.
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