工程弹性类基纳米颗粒显示重链重链单抗体SARS-CoV-2中和重链抗体重链的可变域

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

The final stage of cellular respiration is oxidative phosphorylation that consists of two steps: the electron transport chain and chemiosmosis. The electron transport chain is a set of proteins found in the inner mitochondrial membrane in eukaryotic cells. Its primary function is to establish a proton gradient that can be used during chemiosmosis to produce ATP and generate electron carriers, such as NAD+ and FAD, that are used in glycolysis and the citric acid cycle.
The ETC is comprised of...

The skeletal structure of polymers synthesized via radical polymerization is always branched. For example, the polymerization of ethylene by radical polymerization results in a low-density grade of polyethylene with a heavily branched skeletal structure. Here, the radical site abstracts hydrogen from the growing chain, and the radical site shifts from the end (a primary carbon center) to anywhere within the growing chain (a secondary carbon center). Consequently, the part of the chain from the...

A system of interconnected gears provides a concrete physical interpretation of the Chain Rule in calculus. Consider three gears arranged in sequence, where the rotational speeds of the first, second, and third gears are represented by the variables x, z, and y, respectively. The first gear drives the second, and the second drives the third, so the motion of each gear depends on the one preceding it. This structure naturally leads to a two-stage variable relationship that can be analyzed using...

The thermal expansion of a metal rod shows the application of the Chain Rule when one physical quantity depends on another that varies with time. As the rod is heated, its length changes according to linear thermal expansion, while the temperature of the system varies quadratically with time.For linear thermal expansion, the length L of the rod depends on temperature T such that the rate of change of length with respect to temperature is constant:where L0 = 2 m is the initial length of...

The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...