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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
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Updated: Jan 23, 2026

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
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CRESCENT是一个全面的RNA-Seq表达,拼接和编码/非编码元素网络工具.

Gilles Sireta1, Gwendal Cueff2, Vincent Darbot3

  • 1Université Clermont Auvergne, CNRS, INSERM, iGReD Clermont-Ferrand, Clermont-Ferrand, France.

BMC bioinformatics
|January 21, 2026
PubMed
概括
此摘要是机器生成的。

本研究介绍了CRESCENT,这是一个全面的RNA-Seq分析工具,集成编码和非编码元素,拼接和转录使用. CRESCENT提供了一个可扩展的解决方案,用于在各种物种和计算环境中进行详细的转录基因分析.

关键词:
另一个替代拼接方法.没有编码的RNA.编码蛋白质的基因RNA-Seq 的工作流程.蛇制造者 在做蛇的时候可转移的要素是可以转移的.

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科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 分子生物学分子生物学

背景情况:

  • 传统的RNA-Seq分析往往忽略了诸如可转换元素 (TE) 和非编码RNA等非编码元素.
  • 对拼接事件和转录使用的有限分析阻碍了对转录学调节的完整理解.
  • 需要一个全面的方法来捕捉转录组的全部复杂性.

研究的目的:

  • 开发一个自动化和全面的RNA-Seq分析工作流程.
  • 整合对编码和非编码元素的微分表达式,拼接和转录使用的分析.
  • 提供一个用户友好和可扩展的解决方案,用于转录基因分析.

主要方法:

  • 开发了CRESCENT (综合RNA-seq表达,拼接和编码/非编码元素网络工具),一个Snakemake的工作流.
  • 集成多个生物信息工具和Snakemake包装器,以简化分析.
  • 使用现有数据集验证了工作流,并在各种计算平台上对性能进行了基准测试.

主要成果:

  • 克雷斯能够自动分析微分表达式,替代拼接和转录使用情况.
  • 对蛋白质编码基因,TEs和替代拼接的验证结果与以前的发现一致.
  • 工作流是可扩展的,在个人电脑上运行到高性能计算集群,用于各种测序数据和物种.

结论:

  • 克雷斯提供了一个可扩展和全面的解决方案,用于转录基因分析.
  • 该工具通过整合各种基因组元素,促进了对表达动态的更细致的理解.
  • CRESCENT是免费的,促进了转录基因研究的更广泛的可访问性.