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Updated: Jan 23, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
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综合性转录基因剖析揭示了前列腺癌亚型特定的治疗脆弱性和抵抗机制

Wei Liu1,2, Weiyu Kong3, Silin Jiang1,2

  • 1Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210029, China.

BMC cancer
|January 21, 2026
PubMed
概括

这项研究揭示了前列腺癌 (PCa) 中明显的雄激素受体 (AR) 依赖性,确定了耐治疗亚型和MCL1作为关键驱动因素. 针对AR驱动和AR独立途径的组合疗法对于先进的PCa至关重要.

关键词:
在CRISPR-Cas9屏幕上恩扎拉胺耐药性 耐药性 耐药性在MCL1中,MCL1是MCL1.多个omics的多个omics.前列腺癌是什么意思 前列腺癌是什么意思

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