[在社区居住的老年人中,sarcopenic肥胖现型与轻度认知障碍之间的关联]
1School of Medicine,Wuhan University of Science and Technology,Wuhan 430065, China Hubei Provincial Clinical Research Center for Alzheimer's Disease, Wuhan 430064, China Institute of Advanced Technology of Brain Science, Wuhan University of Science and Technology, Wuhan 430065, China.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
|January 21, 2026
概括
麻症和麻性肥胖症 (SO) 增加了老年人轻度认知障碍 (MCI) 的风险. 农村人口表现出不同的风险,肥胖可能有保护作用,而城市人口面临更高的MCI风险.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 轻度认知障碍 (MCI) 对全球老龄化人口构成重大挑战.
- 标记性肌肉质量和力量的损失和肥胖是老年人中普遍存在的疾病.
- 形肥胖症 (SO) 的综合表型及其与认知衰退的关联需要进一步调查.
研究的目的:
- 在社区居住的老年人中,检查 sarcopenic obesity (SO) 和轻度认知障碍 (MCI) 之间的关系.
- 评估萨科佩尼亚和肥胖对MCI风险的独立和联合影响.
- 根据人口统计学因素 (如年龄和居住环境) 探索这些关联的潜在变化.
主要方法:
- 利用了湖北记忆和衰老队列研究 (2018-2023) 的基线数据.
- 从城市和农村地区招募了2,738名65岁以上的社区成年人,使用集群随机抽样.
- 将参与者分为控制,仅肥胖,仅肉眼和SO组;使用彼得森标准诊断MCI;采用二进制后勤回归和分层分析.
主要成果:
- 与调整后的对照人群相比,只有copenia (OR=1.71) 和 SO (OR=1.60) 与MCI风险增加有关.
- 对于年龄和居住地 (P<0.05) 观察到显著的相互作用.
- 在农村地区,肉症只增加了MCI风险 (OR=1.53),而肥胖只显示出保护作用 (OR=0.72). 在城市地区,SO显著增加了MCI风险 (OR=2.16).
结论:
- 单独的肉症和肉性肥胖症都被确定为老年人MCI的潜在风险因素.
- 这些表型与MCI之间的关联在不同人群和环境中表现出显著的异质性.
- 研究结果强调需要针对性干预,考虑到个体健康状况和生活环境.
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