Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

214
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

269
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
269
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

198
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
198
Ribosome Profiling02:24

Ribosome Profiling

4.1K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.1K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

260
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
260
Taping Over Different Ground Profiles01:12

Taping Over Different Ground Profiles

344
Taping over varying ground profiles requires careful adaptation to achieve accurate measurements. On smooth, level ground with minimal vegetation, the tape can rest directly on the ground. Here, the taping team, typically consisting of a head and a rear tapeman, coordinates their positions with clear communication. The rear tapeman holds the tape at the starting point and guides the head tapeman toward a range pole placed beyond the endpoint, using hand or voice signals to ensure alignment.On...
344

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Non-Invasive Multimarker Strategy Combining IL-17A, Neutrophil-Albumin Ratio, and Fecal Calprotectin for Accurate Discrimination of IBD from IBS-D.

International journal of molecular sciences·2026
Same author

Interleukin 6 Promoter Region Polymorphism in Patients With Type 2 Diabetes Mellitus, Study in One Egyptian Centre.

International journal of immunogenetics·2025
Same author

IKZF1 rs4132601 and rs11978267 gene polymorphisms and paediatric systemic lupus erythematosus; relation to lupus nephritis.

International journal of immunogenetics·2024
Same author

Study of single nucleotide polymorphism of vascular endothelium factor in patients with differentiated thyroid cancer.

Clinical diabetes and endocrinology·2022
Same author

Molecular Detection of Sapovirus in Children Under Five Years with Acute Gastroenteritis in Mansoura, Egypt between January 2019 and February 2020.

F1000Research·2021
Same author

Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome.

F1000Research·2021
Same journal

A 14-Year-old Girl With Neurologic Decline and Unexpected CSF Findings.

The Pediatric infectious disease journal·2026
Same journal

Model-based Differentiation Between Kawasaki Disease and MIS-C: The Importance of the Mitral Valve.

The Pediatric infectious disease journal·2026
Same journal

Pulmonary Embolism in Invasive Salmonella Infection: A Rare Cause of Acute Respiratory Failure in an Adolescent.

The Pediatric infectious disease journal·2026
Same journal

Phase 2/3, Open-label, Randomized, Active-controlled Clinical Trial Evaluating the Safety and Efficacy of Imipenem/Cilastatin/Relebactam in Pediatric Patients From Birth to Less Than 18 Years With Gram-negative Bacterial Infections.

The Pediatric infectious disease journal·2026
Same journal

Determinants of Severity in Pediatric Viral Lower Respiratory Tract Diseases From Emergency Department Presentation to Hospital Course.

The Pediatric infectious disease journal·2026
Same journal

Oropharyngeal Colonization by Kingella kingae and Septic Arthritis in Children 6-48 Months of Age: A Portuguese Multicenter Case-control Study.

The Pediatric infectious disease journal·2026
查看所有相关文章

相关实验视频

Updated: Jan 23, 2026

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes
09:37

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes

Published on: June 19, 2015

9.5K

在儿科 EPEC/STEC 中的 ESBL 和 Integron 配置文件.

Noha Mostafa Mahmoud1, Amira M Sultan1, Maysaa El Sayed Zaki2

  • 1From the Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura.

The Pediatric infectious disease journal
|January 22, 2026
PubMed
概括
此摘要是机器生成的。

腹致大肠杆菌 (DEC) 在埃及引起显著的儿科腹. 发现了抗微生物耐药性,扩展谱β-乳糖酶 (ESBL) 生产和整体载体的高率,需要改进控制措施.

关键词:
埃及 埃及 埃及 埃及抗微生物耐药性 抗微生物耐药性扩展光谱β-乳糖酶的使用整合子是一个整合子.儿科的腹 儿科的腹

更多相关视频

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.4K
Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
03:37

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry

Published on: June 6, 2025

398

相关实验视频

Last Updated: Jan 23, 2026

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes
09:37

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes

Published on: June 19, 2015

9.5K
Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.4K
Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
03:37

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry

Published on: June 6, 2025

398

科学领域:

  • 微生物学 微生物学
  • 传染性疾病 传染性疾病
  • 公共卫生 公共卫生

背景情况:

  • 腹致大肠杆菌 (DEC) 是低收入和中等收入国家的儿童腹的主要原因.
  • 抗微生物耐药性,包括扩展谱β-乳糖酶 (ESBL) 生产,使治疗复杂化.
  • 这项研究的重点是埃及儿童的DEC病型,耐药性,ESBL和整体载体.

研究的目的:

  • 在埃及曼苏拉的急性腹儿童中调查DEC病型的患病率.
  • 为了确定抗菌素耐药性模式,ESBL生产,以及在大肠杆菌分离物中进行整体运输.
  • 了解这些因素之间的关联.

主要方法:

  • 120名患有急性腹的儿童被纳入,便样本培养为大肠杆菌.
  • 进行了表型抗生素敏感性测试和ESBL检测.
  • 聚合酶链反应 (PCR) 试验确定了DEC病型和I/II类整体.

主要成果:

  • 大肠杆菌从50%的儿童中分离出来;滋賀毒素产生大肠杆菌 (STEC) 和典型的肠病原性大肠杆菌 (tEPEC) 主要存在.
  • 对阿莫西西林/克拉夫兰酸,塞法德罗西尔和安皮西林观察到高耐药率.
  • 主要是ESBL生产 (41.7%) 和I/II类整合子 (51.7%/16.7%),整合子与STEC/tEPEC之间有很强的关联.

结论:

  • DEC,特别是STEC和tEPEC,是埃及儿科腹的重要原因.
  • 高抗微生物耐药性,ESBL生产和整体运输突出显示了监测和控制的必要性.
  • 紧急实施监测计划,抗菌药物管理和感染控制至关重要,以限制儿童群体中耐药性传播.