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在儿科 EPEC/STEC 中的 ESBL 和 Integron 配置文件
Noha Mostafa Mahmoud1, Amira M Sultan1, Maysaa El Sayed Zaki2
1From the Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura.
The Pediatric infectious disease journal
|January 22, 2026
概括
腹致大肠杆菌 (DEC) 在埃及引起显著的儿科腹. 发现了抗微生物耐药性,扩展谱β-乳糖酶 (ESBL) 生产和整体载体的高率,需要改进控制措施.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 腹致大肠杆菌 (DEC) 是低收入和中等收入国家的儿童腹的主要原因.
- 抗微生物耐药性,包括扩展谱β-乳糖酶 (ESBL) 生产,使治疗复杂化.
- 这项研究的重点是埃及儿童的DEC病型,耐药性,ESBL和整体载体.
研究的目的:
- 在埃及曼苏拉的急性腹儿童中调查DEC病型的患病率.
- 为了确定抗菌素耐药性模式,ESBL生产,以及在大肠杆菌分离物中进行整体运输.
- 了解这些因素之间的关联.
主要方法:
- 120名患有急性腹的儿童被纳入,便样本培养为大肠杆菌.
- 进行了表型抗生素敏感性测试和ESBL检测.
- 聚合酶链反应 (PCR) 试验确定了DEC病型和I/II类整体.
主要成果:
- 大肠杆菌从50%的儿童中分离出来;滋賀毒素产生大肠杆菌 (STEC) 和典型的肠病原性大肠杆菌 (tEPEC) 主要存在.
- 对阿莫西西林/克拉夫兰酸,塞法德罗西尔和安皮西林观察到高耐药率.
- 主要是ESBL生产 (41.7%) 和I/II类整合子 (51.7%/16.7%),整合子与STEC/tEPEC之间有很强的关联.
结论:
- DEC,特别是STEC和tEPEC,是埃及儿科腹的重要原因.
- 高抗微生物耐药性,ESBL生产和整体运输突出显示了监测和控制的必要性.
- 紧急实施监测计划,抗菌药物管理和感染控制至关重要,以限制儿童群体中耐药性传播.
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