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菌体vB_SalS_KY05可以控制家禽中的沙门氏菌,而不会破坏菌体微生物群的组成

Wun-Yuan Wu¹, Reuben Wang^2,3,4, Yu-Ning An²

¹Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan.

The veterinary quarterly

|January 22, 2026

概括

一个新的菌体,vB_SalS_KY05,显示出作为家禽生物控制剂对沙门氏菌的承诺. 低剂量菌体治疗有效地减少了的沙门氏菌,并促进了有益的肠道细菌,而高剂量导致了共存.

科学领域:

兽医微生物学兽医微生物学
细菌治疗疗法是一种细菌治疗.
食品安全食品安全

背景情况:

沙门氏菌在家禽生产中构成重大食品安全风险.
抗生素耐药性需要开发替代控制策略.
菌体为管理牲畜中的细菌病原体提供了潜在的解决方案.

研究的目的:

为了描述多价Tequintavirus的特征vB_SalS_KY05.
评估其对禽类沙门氏菌和大肠杆菌的疗效.
评估其在家禽养殖中作为生物控制剂的潜力.

主要方法:

对vB_SalS_KY05进行基因组分析,以检测化活性和毒性基因的缺失.
在各种环境条件下 (pH,温度,时间) 对菌体的稳定性测试.
在体内对的疗效研究,这些受到沙门氏菌 Typhimurium 的挑战,使用低 (10^5 PFU/mL) 和高 (10^8 PFU/mL) 菌体剂量.

主要成果:

vB_SalS_KY05表现出稳定性和没有毒性或抗性基因的活跃生活方式.
低剂量菌体治疗显著降低了脏沙门氏菌,改善了白蛋白与血球蛋白的比率,并丰富了有益的肠道细菌 (Lactobacillus crispatus,Blautia coccoides).
高剂量治疗导致了菌-细菌的共存和潜在有害细菌 (Erysipelatoclostridium) 的增加,对整体菌群的影响最小.

结论:

vB_SalS_KY05是一种有前途的禽类生物控制剂,对沙门氏菌有效.
优化菌体剂量对于最大限度地控制病原体和保持肠道微生物群稳定性至关重要.
这项研究强调了菌体治疗作为家禽生产中抗生素的可持续替代品的潜力.

关键词:

沙门氏菌是一种沙门氏菌.抗生素替代品抗生素替代品细菌菌体是一种菌体.禽类禽类禽类禽类

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