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Updated: Jan 23, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
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Published on: February 2, 2014

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在小鼠中,mRNA疫苗诱导的不良反应的炎症媒介

Koyo Honda1, Tatsuya Karaki2, Yuta Kunishima2

  • 1Laboratory of Nano-design for Innovative Drug Development, Graduate School of Pharmaceutical Sciences, The University of Osaka; 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, The University of Osaka; 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Molecular therapy : the journal of the American Society of Gene Therapy
|January 22, 2026
PubMed
概括

mRNA疫苗可能会引起像发烧这样的副作用,在增强剂后通常会恶化. 这项研究揭示了脂质纳米颗粒 (LNP) 驱动这些反应,识别了关键的炎症介质. 抑制IL-6可以减少副作用,同时保持疫苗的疗效.

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