一个集成的NIR-II无光报告器用于多模式成像引导的乳房保护手术
Xinwei Wang1, Kexin Shi1, Ye Wang1
1Department of Immunology, School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Nano letters
|January 22, 2026
概括
这项研究介绍了一种新的无光记者,用于增强乳腺癌手术. 开发的三模纳米探针 (RPM纳米颗粒) 精确地划分瘤边缘,确保完整的瘤切除并改善外科手术结果.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 医疗成像医学成像
背景情况:
- 精确的瘤边缘划分对于成功的乳房保护手术至关重要.
- 目前的方法在准确识别瘤边界方面面临挑战.
- 需要先进的成像技术来提高手术准确性和患者的治疗结果.
研究的目的:
- 开发一种新的无光三极管纳米探针,用于增强乳腺瘤边缘划分.
- 整合磁共振成像 (MRI),光声成像 (PAI) 和拉曼散射成像.
- 为了提高乳腺癌手术中瘤切除的准确性和完整性.
主要方法:
- 开发含的NiS8纳米粒子,用于无光成像.
- 在RPM纳米粒子中集成用于三模成像 (MRI-PAI-Raman).
- 术前MRI用于瘤定位,术后PAI/Raman用于边缘划分,术后Raman用于验证.
主要成果:
- NiS8纳米粒子表现出强烈的光子共振吸收和非发射,使得无光成像.
- RPM纳米粒子证明了改善的拉曼/PAI特性和信号相关性.
- 成功的手术前瘤鉴定,手术内边缘划定,以及术后完全切除的验证.
结论:
- 开发的无光三模纳米探针 (RPM纳米颗粒) 为精确的乳腺瘤边缘划分提供了有前途的解决方案.
- 这种方法提高了手术规划和执行,从而改善了瘤切除.
- 三模成像策略有助于准确识别和验证无瘤边缘,最终验证完整的瘤去除.
更多相关视频
03:07Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
Published on: August 19, 2025
853
09:41A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
Published on: May 20, 2016
12.7K
相关概念视频
What is Conservation Biology?
24.0K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.0K
Conservation of Small Populations
16.7K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
16.7K
Conserved Binding Sites
5.0K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.0K
Conservation of Protein Domains Over Different Proteins
14.1K
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.1K
Conservative Forces
949
Conservative forces are an essential concept in the field of mechanical engineering. Understanding the properties and characteristics of these forces is crucial to the design and analysis of mechanical systems.
Conservative forces are forces that are dependent only on the initial and final positions of an object and that are independent of the path that the object takes between these positions. These forces conserve energy, which means that the work done by the force is independent of the path...
Conservative forces are forces that are dependent only on the initial and final positions of an object and that are independent of the path that the object takes between these positions. These forces conserve energy, which means that the work done by the force is independent of the path...
949
Conservative Forces
14.0K
According to the law of conservation of energy, any transition between kinetic and potential energy conserves the total energy of the system. Hence, the work done by a conservative force is completely reversible. It is path independent, which means that we can start and stop at any two points in the transition, and the total energy of the system (kinetic plus potential energy at these points) will remain conserved. This is characteristic of a conservative force. Some important examples of...
14.0K
